Heseltine, Thomas, Hughes, Elen, Mattew, Jean, Murray, Scott, Ortega-Martorell, Sandra 
ORCID: 0000-0001-9927-3209, Olier, Ivan, Dey, Damini, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Khoo, Saye ORCID: 0000-0002-2769-0967
(2023)
The association of epicardial adipose tissue volume and density with coronary calcium in HIV-positive and HIV-negative patients.
JOURNAL OF INFECTION, 86 (4).
pp. 376-384.
Abstract
<h4>Aims</h4>We sought to assess and compare the association of epicardial adipose tissue (EAT) with cardiovascular disease (CVD) in HIV-positive and HIV-negative groups.<h4>Methods and results</h4>Using existing clinical databases, we analyzed 700 patients (195 HIV-positive, 505 HIV-negative). CVD was quantified by the presence of coronary calcification from both dedicated cardiac computed tomography (CT) and non-dedicated CT of the thorax. Epicardial adipose tissue (EAT) was quantified using dedicated software. The HIV-positive group had lower mean age (49.2 versus 57.8, p < 0.005), higher proportion of male sex (75.9 % versus 48.1 %, p < 0.005), and lower rates of coronary calcification (29.2 % versus 58.2 %, p < 0.005). Mean EAT volume was also lower in the HIV-positive group (68mm3 versus 118.3mm3, p < 0.005). Multiple linear regression demonstrated EAT volume was associated with hepatosteatosis (HS) in the HIV-positive group but not the HIV-negative group after adjustment for BMI (p < 0.005 versus p = 0.066). In the multivariate analysis, after adjustment for CVD risk factors, age, sex, statin use, and body mass index (BMI), EAT volume and hepatosteatosis were significantly associated with coronary calcification (odds ratio [OR] 1.14, p < 0.005 and OR 3.17, p < 0.005 respectively). In the HIV-negative group, the only significant association with EAT volume after adjustment was total cholesterol (OR 0.75, p = 0.012).<h4>Conclusions</h4>We demonstrated a strong and significant independent association of EAT volume and coronary calcium, after adjustment, in HIV-positive group but not in the HIV-negative group. This result hints at differences in the mechanistic drivers of atherosclerosis between HIV-positive and HIV-negative groups.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIV, Epicardial adipose tissue, Coronary artery disease |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 21 Apr 2023 08:50 |
| Last Modified: | 09 Jun 2023 09:20 |
| DOI: | 10.1016/j.jinf.2023.02.020 |
| Open Access URL: | https://researchonline.ljmu.ac.uk/id/eprint/18936/ |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3169824 |
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