Mason, Lewis CE 
ORCID: 0000-0001-5049-1352, Greig, David R, Cowley, Lauren A, Partridge, Sally R, Martinez, Elena, Blackwell, Grace A, Chong, Charlotte E ORCID: 0000-0001-8402-3936, De Silva, P Malaka ORCID: 0000-0002-0579-0131, Bengtsson, Rebecca J, Draper, Jenny L et al (show 13 more authors)
(2023)
The evolution and international spread of extensively drug resistant Shigella sonnei.
Nature communications, 14 (1).
p. 1983.
Abstract
Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common including against World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently, an MSM-associated outbreak of extended-spectrum β-lactamase producing, extensively drug resistant S. sonnei was reported in the United Kingdom. Here, we aimed to identify the genetic basis, evolutionary history, and international dissemination of the outbreak strain. Our genomic epidemiological analyses of 3,304 isolates from the United Kingdom, Australia, Belgium, France, and the United States of America revealed an internationally connected outbreak with a most recent common ancestor in 2018 carrying a low-fitness cost resistance plasmid, previously observed in travel associated sublineages of S. flexneri. Our results highlight the persistent threat of horizontally transmitted antimicrobial resistance and the value of continuing to work towards early and open international sharing of genomic surveillance data.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Shigella, Shigella sonnei, Anti-Bacterial Agents, Microbial Sensitivity Tests, Homosexuality, Male, Drug Resistance, Bacterial, Travel, Male, Sexual and Gender Minorities |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology > School of Life Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 21 Apr 2023 09:11 |
| Last Modified: | 18 Oct 2023 19:16 |
| DOI: | 10.1038/s41467-023-37672-w |
| Open Access URL: | https://doi.org/10.1038/s41467-023-37672-w |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3169833 |
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