Irish funder guidance increased searching for, and uptake of, core outcome sets

Beecher, Claire, Galvin, Sandra, Cody, Anne, Williamson, Paula R ORCID: 0000-0001-9802-6636, Hughes, Karen, Ward, Oonagh, Creely, Caitriona and Devane, Declan (2023) Irish funder guidance increased searching for, and uptake of, core outcome sets. JOURNAL OF CLINICAL EPIDEMIOLOGY, 158. pp. 92-98.

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Official URL: http://dx.doi.org/10.1016/j.jclinepi.2023.03.019

Abstract

<h4>Objectives</h4>Assess the impact of the Health Research Board (HRB) Ireland guidance on the uptake of core outcome sets (COSs).<h4>Study design and setting</h4>(1) Information on COS use, searching of the Core Outcome Measures in Effectiveness Trials (COMET) database, and rationale for outcome selection were extracted from HRB funding applications (2) COMET was searched for relevant COS availability at the time of application or developed since (3) principal investigator choices were explored through online surveys.<h4>Results</h4>Out of 187 funding applications, 44% (n = 82) searched the COMET database, and 13% (n = 11) of those found a relevant COS to inform their outcomes. Four applicants proposed COS development. However, 84% (n = 156) of applications had no relevant COS available at the time of submission, as identified by subsequent author COMET search. Among 84 principal investigators who participated in the surveys, 10 (12%) found and used a COS and 19 (42%) of the 45 respondents who did not have reference to COMET had searched the COMET database. A new question in the application form prompted a rise in those reporting a search of the COMET database from 6% to 99%.<h4>Conclusion</h4>The study found low COS uptake in funding applications, but a new application question prompted an increase in reporting searches of the COMET database. Funder guidance promoted COS awareness and use, but more efforts are needed to facilitate COS development and adoption in clinical research.

Item Type:	Article
Uncontrolled Keywords:	Core outcome set, Outcome measures, Randomized controlled trial, Research funding, COS, Trial outcomes
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health
Depositing User:	Symplectic Admin
Date Deposited:	24 Apr 2023 09:31
Last Modified:	14 Jun 2023 22:49
DOI:	10.1016/j.jclinepi.2023.03.019
Open Access URL:	https://doi.org/10.1016/j.jclinepi.2023.03.019
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169913