Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children

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Wilson, Kyle ORCID: 0000-0003-0151-7530, Tu, Zhanhan, Mbale, Emmie, Mhango, Priscilla, Kayange, Petros, Gladstone, Melissa ORCID: 0000-0002-2579-9301, Harding, Simon ORCID: 0000-0003-4676-1158, Gottlob, Irene, Garcia-Finana, Marta ORCID: 0000-0003-4939-0575, Shen, Yaochun ORCID: 0000-0002-8915-1993 et al (show 4 more authors) , Taylor, Terrie, Seydel, Karl, Zheng, Yalin ORCID: 0000-0002-7873-0922 and Beare, Nicholas AV ORCID: 0000-0001-8086-990X (2023) Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children. Wellcome Open Research, 8. p. 172.

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Abstract

Cerebral malaria (CM) remains a significant global health challenge with high morbidity and mortality. Malarial retinopathy has been shown to be diagnostically and prognostically significant in the assessment of CM. The major mechanism of death in paediatric CM is brain swelling. Long term morbidity is typically characterised by neurological and neurodevelopmental sequelae. Optical coherence tomography can be used to quantify papilloedema and macular ischaemia, identified as hyperreflectivity. Here we describe a protocol to test the hypotheses that quantification of optic nerve head swelling using optical coherence tomography can identify severe brain swelling in CM, and that quantification of hyperreflectivity in the macula predicts neurodevelopmental outcomes post-recovery. Additionally, our protocol includes the development of a novel, low-cost, handheld optical coherence tomography machine and artificial intelligence tools to assist in image analysis.

Item Type:	Article
Uncontrolled Keywords:	artificial intelligence, brain swelling, cerebral malaria, intracranial pressure, malarial retinopathy, optical coherence tomography
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	15 May 2023 09:09
Last Modified:	26 Sep 2023 15:42
DOI:	10.12688/wellcomeopenres.19166.1
Open Access URL:	http://search.crossref.org/?q=10.12688%2Fwellcomeo...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3170239