Fawzy, Ameenathul MM, Bisson, Arnaud 
ORCID: 0000-0002-3449-1800, Bodin, Alexandre, Herbert, Julien, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Fauchier, Laurent
(2023)
Atrial Fibrillation and the Risk of Ventricular Arrhythmias and Cardiac Arrest: A Nationwide Population-Based Study.
JOURNAL OF CLINICAL MEDICINE, 12 (3).
1075-.
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Abstract
<h4>Background</h4>Atrial fibrillation (AF) has been linked to an increased risk of ventricular arrhythmias (VAs) and sudden death. We investigated this association in hospitalised patients in France.<h4>Methods</h4>All hospitalised patients from 2013 were identified from the French National database and included if they had at least 5 years of follow-up data.<h4>Results</h4>Overall, 3,381,472 patients were identified. After excluding 35,834 with a history of VAs and cardiac arrest, 3,345,638 patients were categorised into two groups: no AF (<i>n</i> = 3,033,412; mean age 57.2 ± 21.4; 54.3% female) and AF (<i>n</i> = 312,226; 78.1 ± 10.6; 44.0% female). Over a median follow-up period of 5.4 years (interquartile range (IQR) 5.0-5.8 years), the incidence (2.23%/year vs. 0.56%/year) and risk (hazard ratio (HR) 3.657 (95% confidence interval (CI) 3.604-3.711)) of VAs and cardiac arrest were significantly higher in AF patients compared to non-AF patients. This was still significant after adjusting for confounders, with a HR of 1.167 (95% CI 1.111-1.226) and in the 1:1 propensity score-matched analysis (<i>n</i> = 289,332 per group), with a HR of 1.339 (95% CI 1.313-1.366). In the mediation analysis, the odds of cardiac arrest were significantly mediated by AF-associated VAs, with an OR of 1.041 (95% CI 1.040-1.042).<h4>Conclusion</h4>In hospitalised French patients, AF was associated with an increased risk of VAs and sudden death.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | atrial fibrillation, sudden death, cardiac arrest, ventricular tachycardia, ventricular fibrillation, arrhythmias |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 18 May 2023 09:42 |
| Last Modified: | 18 May 2023 09:42 |
| DOI: | 10.3390/jcm12031075 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3170475 |
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