Circulating Histones to Detect and Monitor the Progression of Cancer

Tsoneva, Desislava KK, Ivanov, Martin NN, Conev, Nikolay Vladimirov, Manev, Rostislav, Stoyanov, Dragomir Svetozarov and Vinciguerra, Manlio ORCID: 0000-0002-1768-3894 (2023) Circulating Histones to Detect and Monitor the Progression of Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (2). 942-.

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Official URL: http://dx.doi.org/10.3390/ijms24020942

Abstract

Liquid biopsies have emerged as a minimally invasive cancer detection and monitoring method, which could identify cancer-related alterations in nucleosome or histone levels and modifications in blood, saliva, and urine. Histones, the core component of the nucleosome, are essential for chromatin compaction and gene expression modulation. Increasing evidence suggests that circulating histones and histone complexes, originating from cell death or immune cell activation, could act as promising biomarkers for cancer detection and management. In this review, we provide an overview of circulating histones as a powerful liquid biopsy approach and methods for their detection. We highlight current knowledge on circulating histones in hematologic malignancies and solid cancer, with a focus on their role in cancer dissemination, monitoring, and tumorigenesis. Last, we describe recently developed strategies to identify cancer tissue-of-origin in blood plasma based on nucleosome positioning, inferred from nucleosomal DNA fragmentation footprint, which is independent of the genetic landscape.

Item Type:	Article
Uncontrolled Keywords:	liquid biopsy, histones, cell-free DNA, cancer
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	18 May 2023 10:14
Last Modified:	18 May 2023 10:14
DOI:	10.3390/ijms24020942
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3170481