Features of Clinical Complexity in European Patients with Atrial Fibrillation: A Report from a European Observational Prospective AF Registry.

Proietti, Marco ORCID: 0000-0003-1452-2478, Romiti, Giulio Francesco, Corica, Bernadette, Mei, Davide Antonio, Bonini, Niccolò, Vitolo, Marco, Imberti, Jacopo Francesco, Boriani, Giuseppe and Lip, Gregory YH ORCID: 0000-0002-7566-1626 (2023) Features of Clinical Complexity in European Patients with Atrial Fibrillation: A Report from a European Observational Prospective AF Registry. Current problems in cardiology, 48 (8). p. 101752.

Access the full-text of this item by clicking on the Open Access link.

Official URL: http://dx.doi.org/10.1016/j.cpcardiol.2023.101752

Abstract

There is increasing concern regarding impact of clinical complexity in patients with atrial fibrillation (AF). We explored the impact of different clinical complexity features in AF patients. We analyzed patients from a prospective, observational, multicentre Europe-wide AF registry. Features of clinical complexity among patients with CHA<sub>2</sub>DS<sub>2</sub>-VASc ≥2 were: i) history of bleeding; ii) frailty; iii) chronic kidney disease (CKD); iv) ≥2 features. A total of 10,169 patients were analysed. Of these, 141 (1.4%) had history of bleeding, 954 (9.4%) were frail, 1,767 (17.4%) had CKD and 1,253 (12.3%) had ≥2 features. All features of clinical complexity were less treated with OAC. History of bleeding (HR 1.94, 95% CI 1.32-2.85), frailty (HR 1.38, 95% CI 1.11-1.71), CKD (HR 1.50, 95% 1.28-1.75) and ≥2 features (HR 2.08, 95% CI 1.73-2.51) were associated with outcomes. Presence of features of clinical complexity is associated with lower use of OAC and higher risk of outcomes.

Item Type:	Article
Uncontrolled Keywords:	Humans, Atrial Fibrillation, Hemorrhage, Anticoagulants, Registries, Risk Assessment, Risk Factors, Prospective Studies, Renal Insufficiency, Chronic, Multicenter Studies as Topic, Stroke, Frailty
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	25 May 2023 10:15
Last Modified:	24 Jun 2023 00:32
DOI:	10.1016/j.cpcardiol.2023.101752
Open Access URL:	https://doi.org/10.1016/j.cpcardiol.2023.101752
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3170662