Tchetgna, Huguette Simo, Yousseu, Francine Sado, Kamgang, Basile, Tedjou, Armel, McCall, Philip J 
ORCID: 0000-0002-0007-3985 and Wondji, Charles S
(2021)
Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.
PLOS NEGLECTED TROPICAL DISEASES, 15 (10).
e0009860-.
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Abstract
Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using real time RT-PCR on fragments of the 5' and 3' UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. Phylogenetic analysis of the envelope gene identified DENV-1 as belonging to genotype V, DENV-2 to genotype II and DENV-3 to genotype III. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region.
| Item Type: | Article |
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| Uncontrolled Keywords: | Humans, Dengue Virus, Dengue, Phylogeny, Genotype, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Child, Preschool, Infant, Cameroon, Female, Male, Young Adult, Coinfection, Serogroup |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Jul 2023 14:16 |
| Last Modified: | 06 Jul 2023 14:16 |
| DOI: | 10.1371/journal.pntd.0009860 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3171468 |
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