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ORCID: 0000-0003-4478-3601, Amaratunga, Chanaki, Amenga-Etego, Lucas ORCID: 0000-0003-4468-0506 et al (show 163 more authors) , Andagalu, Ben, Anderson, Tim ORCID: 0000-0002-0191-0204, Andrianaranjaka, Voahangy, Aniebo, Ifeyinwa, Aninagyei, Enoch, Ansah, Felix, Ansah, Patrick O ORCID: 0000-0002-3214-5621, Apinjoh, Tobias, Arnaldo, Paulo, Ashley, Elizabeth ORCID: 0000-0002-7620-4822, Auburn, Sarah, Awandare, Gordon A, Ba, Hampate ORCID: 0000-0002-9299-5775, Baraka, Vito ORCID: 0000-0001-9694-9293, Barry, Alyssa, Bejon, Philip ORCID: 0000-0002-2135-7549, Bertin, Gwladys I ORCID: 0000-0002-2218-9591, Boni, Maciej F ORCID: 0000-0002-0830-9630, Borrmann, Steffen, Bousema, Teun ORCID: 0000-0003-2666-094X, Bouyou-Akotet, Marielle, Branch, Oralee, Bull, Peter C, Cheah, Huch, Chindavongsa, Keobouphaphone, Chookajorn, Thanat ORCID: 0000-0003-2876-6203, Chotivanich, Kesinee, Claessens, Antoine ORCID: 0000-0002-4277-0914, Conway, David J ORCID: 0000-0002-8711-3037, Corredor, Vladimir, Courtier, Erin, Craig, Alister ORCID: 0000-0003-0914-6164, D'Alessandro, Umberto ORCID: 0000-0001-6341-5009, Dama, Souleymane, Day, Nicholas ORCID: 0000-0003-2309-1171, Denis, Brigitte, Dhorda, Mehul, Diakite, Mahamadou ORCID: 0000-0002-4268-8857, Djimde, Abdoulaye ORCID: 0000-0003-0062-2283, Dolecek, Christiane, Dondorp, Arjen ORCID: 0000-0001-5190-2395, Doumbia, Seydou, Drakeley, Chris ORCID: 0000-0003-4863-075X, Drury, Eleanor, Duffy, Patrick, Echeverry, Diego F ORCID: 0000-0003-0301-4478, Egwang, Thomas G, Enosse, Sonia Maria Mauricio, Erko, Berhanu ORCID: 0000-0003-1685-752X, Fairhurst, Rick M, Faiz, Abdul ORCID: 0000-0002-3460-7535, Fanello, Caterina A ORCID: 0000-0003-1932-9562, Fleharty, Mark, Forbes, Matthew, Fukuda, Mark, Gamboa, Dionicia ORCID: 0000-0002-1420-7729, Ghansah, Anita, Golassa, Lemu ORCID: 0000-0002-1216-8711, Goncalves, Sonia, Harrison, GL Abby, Healy, Sara Anne ORCID: 0000-0003-3078-6094, Hendry, Jason A, Hernandez-Koutoucheva, Anastasia, Hien, Tran Tinh, Hill, Catherine A, Hombhanje, Francis, Hott, Amanda, Htut, Ye, Hussein, Mazza, Imwong, Mallika, Ishengoma, Deus ORCID: 0000-0003-2040-3416, Jackson, Scott A ORCID: 0000-0002-3172-1607, Jacob, Chris G, Jeans, Julia, Johnson, Kimberly J, Kamaliddin, Claire ORCID: 0000-0001-8198-6235, Kamau, Edwin ORCID: 0000-0002-5761-7883, Keatley, Jon, Kochakarn, Theerarat, Konate, Drissa S ORCID: 0000-0002-4177-9642, Konaté, Abibatou, Kone, Aminatou, Kwiatkowski, Dominic P ORCID: 0000-0002-5023-0176, Kyaw, Myat P, Kyle, Dennis ORCID: 0000-0002-0238-965X, Lawniczak, Mara ORCID: 0000-0002-3006-2080, Lee, Samuel K, Lemnge, Martha, Lim, Pharath, Lon, Chanthap, Loua, Kovana M ORCID: 0000-0003-0571-0944, Mandara, Celine I, Marfurt, Jutta, Marsh, Kevin ORCID: 0000-0001-8377-5466, Maude, Richard James ORCID: 0000-0002-5355-0562, Mayxay, Mayfong ORCID: 0000-0002-6056-4516, Maïga-Ascofaré, Oumou, Miotto, Olivo ORCID: 0000-0001-8060-6771, Mita, Toshihiro ORCID: 0000-0001-8180-2344, Mobegi, Victor ORCID: 0000-0002-1962-5583, Mohamed, Abdelrahim Osman, Mokuolu, Olugbenga A, Montgomery, Jaqui, Morang'a, Collins Misita ORCID: 0000-0002-6988-150X, Mueller, Ivo, Murie, Kathryn ORCID: 0009-0008-9612-2016, Newton, Paul N, Ngo Duc, Thang, Nguyen, Thuy, Nguyen, Thuy-Nhien ORCID: 0000-0002-4101-5706, Nguyen Thi Kim, Tuyen, Nguyen Van, Hong, Noedl, Harald, Nosten, Francois ORCID: 0000-0002-7951-0745, Noviyanti, Rintis, Ntui, Vincent Ntui-Njock ORCID: 0000-0002-7532-9930, Nzila, Alexis, Ochola-Oyier, Lynette Isabella, Ocholla, Harold, Oduro, Abraham ORCID: 0000-0002-4191-7419, Omedo, Irene, Onyamboko, Marie A ORCID: 0000-0002-7501-5931, Ouedraogo, Jean-Bosco ORCID: 0000-0003-0412-8733, Oyebola, Kolapo ORCID: 0000-0002-1003-2570, Oyibo, Wellington Aghoghovwia, Pearson, Richard ORCID: 0000-0002-7386-3566, Peshu, Norbert, Phyo, Aung P ORCID: 0000-0002-0383-9624, Plowe, Christopher V, Price, Ric N ORCID: 0000-0003-2000-2874, Pukrittayakamee, Sasithon, Quang, Huynh Hong, Randrianarivelojosia, Milijaona, Rayner, Julian C ORCID: 0000-0002-9835-1014, Ringwald, Pascal, Rosanas-Urgell, Anna ORCID: 0000-0002-0432-5203, Rovira-Vallbona, Eduard, Ruano-Rubio, Valentin, Ruiz, Lastenia, Saunders, David, Shayo, Alex ORCID: 0000-0002-7099-8537, Siba, Peter, Simpson, Victoria J, Sissoko, Mahamadou S, Smith, Christen, Su, Xin-Zhuan ORCID: 0000-0003-3246-3248, Sutherland, Colin, Takala-Harrison, Shannon, Talman, Arthur, Tavul, Livingstone, Thanh, Ngo Viet, Thathy, Vandana, Thu, Aung Myint, Toure, Mahamoudou, Tshefu, Antoinette, Verra, Federica, Vinetz, Joseph ORCID: 0000-0001-8344-2004, Wellems, Thomas E ORCID: 0000-0003-3899-8454, Wendler, Jason, White, Nicholas J, Whitton, Georgia ORCID: 0009-0001-9456-6376, Yavo, William and van der Pluijm, Rob W
(2023)
Pf7: an open dataset of <i>Plasmodium falciparum</i> genome variation in 20,000 worldwide samples.
Wellcome open research, 8.
22-.
![[img]](http://livrepository.liverpool.ac.uk/3171494/1.hassmallThumbnailVersion/Pf7%20an%20open%20dataset%20of%20iPlasmodium%20falciparumi%20genome%20variation%20in%2020%2C000%20worldwide%20samples.pdf) |
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Pf7 an open dataset of iPlasmodium falciparumi genome variation in 20,000 worldwide samples.pdf
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Abstract
We describe the MalariaGEN Pf7 data resource, the seventh release of <i>Plasmodium falciparum</i> genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations. We identify a large number of newly emerging <i>crt</i> mutations in parts of Southeast Asia, and show examples of heterogeneities in patterns of drug resistance within Africa and within the Indian subcontinent. We describe the profile of variations in the C-terminal of the <i>csp</i> gene and relate this to the sequence used in the RTS,S and R21 malaria vaccines. Pf7 provides high-quality data on genotype calls for 6 million SNPs and short indels, analysis of large deletions that cause failure of rapid diagnostic tests, and systematic characterisation of six major drug resistance loci, all of which can be freely downloaded from the MalariaGEN website.
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