Johnson, James R and Barclay, Jeff W
(2023)
<i>C. elegans dkf-1</i> (Protein Kinase D1) mutants have age-dependent defects in locomotion and neuromuscular transmission.
microPublication biology, 2023.
10.17912/micropub.biology.000800-.
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Abstract
Changes in neuronal function that occur with age are an area of increasing importance. A potential significant contributor to age-dependent decline may be alterations to neurotransmitter release. Protein kinases, such as Protein Kinase C and Protein Kinase A, are well characterised modulators of neuronal function and neurotransmission. Protein Kinase D (PRKD) is a serine/threonine kinase whose role in neurons is less well characterised. Here we report that mutations in the <i>C. elegans</i> PRKD homolog, <i>dkf-1</i> , show an acceleration in age-dependent decline of locomotion rate and an alteration to age-dependent changes in aldicarb sensitivity. These effects could be explained by a pre- or post-synaptic function of the protein kinase as the animal ages.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Aging, Neurosciences, 1.1 Normal biological development and functioning, 1 Underpinning research, Neurological |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Jul 2023 15:49 |
| Last Modified: | 17 Mar 2024 16:29 |
| DOI: | 10.17912/micropub.biology.000800 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3171511 |
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