Middleton, Bianca F, Danchin, Margie, Cunliffe, Nigel A 
ORCID: 0000-0002-5449-4988, Jones, Mark A, Boniface, Karen, Kirkwood, Carl D, Gallagher, Sarah, Kirkham, Lea-Ann, Granland, Caitlyn, McNeal, Monica et al (show 5 more authors)
(2023)
Histo-blood group antigen profile of Australian Aboriginal children and seropositivity following oral rotavirus vaccination.
VACCINE, 41 (24).
pp. 3579-3583.
Abstract
<h4>Background</h4>Histo-blood group antigens (HBGAs) may influence immune responses to rotavirus vaccination.<h4>Methods</h4>HBGA phenotyping was determined by detection of antigens A, B, H and Lewis a and b in saliva using enzyme-linked immunosorbent assay. Secretor status was confirmed by lectin antigen assay if A, B and H antigens were negative or borderline (OD ± 0.1 of threshold of detection). PCR-RFLP analysis was used to identify the FUT2 'G428A' mutation in a subset. Rotavirus seropositivity was defined as serum anti-rotavirus IgA ≥ 20 AU/mL.<h4>Results</h4>Of 156 children, 119 (76 %) were secretors, 129 (83 %) were Lewis antigen positive, and 105 (67 %) were rotavirus IgA seropositive. Eighty-seven of 119 (73 %) secretors were rotavirus seropositive, versus 4/9 (44 %) weak secretors and 13/27 (48 %) non-secretors.<h4>Conclusions</h4>Most Australian Aboriginal children were secretor and Lewis antigen positive. Non-secretor children were less likely to be seropositive to rotavirus antibodies following vaccination, but this phenotype was less common. HBGA status is unlikely to fully explain underperformance of rotavirus vaccines among Australian Aboriginal children.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Rotavirus, Rotavirus vaccine, Histo-blood group antigen, Aboriginal, Australia |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 Jul 2023 15:12 |
| Last Modified: | 12 Jul 2023 18:54 |
| DOI: | 10.1016/j.vaccine.2023.05.007 |
| Open Access URL: | https://pubmed.ncbi.nlm.nih.gov/37179162/ |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3171528 |
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