Surveillance for Presumed BD-IPMN of the Pancreas: Stability, Size, and Age Identify Targets for Discontinuation.


Marchegiani, Giovanni, Pollini, Tommaso, Burelli, Anna, Han, Youngmin, Jung, Hye-Sol, Kwon, Wooil, Rocha Castellanos, Dario Missael, Crippa, Stefano, Belfiori, Giulio, Arcidiacono, Paolo Giorgio et al (show 28 more authors) (2023) Surveillance for Presumed BD-IPMN of the Pancreas: Stability, Size, and Age Identify Targets for Discontinuation. Gastroenterology, 165 (4). S0016-5085(23)00935-6-S0016-5085(23)00935-6.

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Abstract

<h4>Background and aims</h4>Currently, most patients with branch duct intraductal papillary mucinous neoplasms (BD-IPMN) are offered indefinite surveillance, resulting in health care costs with questionable benefits regarding cancer prevention. This study sought to identify patients where the risk of cancer is equivalent to an age-matched population, thereby justifying discontinuation of surveillance.<h4>Methods</h4>International multicenter study involving presumed BD-IPMN without worrisome features (WF) or high-risk stigmata (HRS) at diagnosis who underwent surveillance. Clusters of individuals at risk for cancer development were defined according to cyst size and stability for at least 5 years, and age-matched controls were used for comparison using standardized incidence ratios (SIRs) for pancreatic cancer.<h4>Results</h4>Of 3844 patients with presumed BD-IPMN, 775 (20.2%) developed WF and 68 (1.8%) HRS after a median surveillance of 53 (IQR 53) months. Some 164 patients (4.3%) underwent surgery. Of the overall cohort, 1617 patients (42%) remained stable without developing WF or HRS for at least 5 years. In patients 75 years or older, the SIR was 1.12 (95%CI 0.23-3.39), and in patients 65 years or older with stable lesions below 15mm in diameter after 5 years, the SIR was 0.95 (95%CI 0.11-3.42). The all-cause mortality for patients who did not develop WF or HRS for at least 5 years was 4.9% (n= 79), while the disease-specific mortality was 0.3% (n=5).<h4>Conclusions</h4>The risk of developing pancreatic malignancy in presumed BD-IPMN without WF or HRS after 5 years of surveillance is comparable to that of the general population depending on cyst size and patient age. Surveillance discontinuation could be justified after 5 years of stability in patients older than 75 years with cysts < 30 mm, and in patients 65 years or older who have cysts ≤ 15 mm.

Item Type: Article
Uncontrolled Keywords: Pancreas, Pancreatic Ducts, Humans, Cysts, Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms, Retrospective Studies, Pancreatic Intraductal Neoplasms
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 07 Jul 2023 15:01
Last Modified: 29 Sep 2023 08:50
DOI: 10.1053/j.gastro.2023.06.022
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3171531
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