Kaczmarek, Mathieu, Halimi, Jean-Michel, de Freminville, Jean-Baptiste, Gatault, Philippe, Gueguen, Juliette, Goin, Nicolas, Longuet, Helene, Barbet, Christelle, Bisson, Arnaud 
ORCID: 0000-0002-3449-1800, Sautenet, Benedicte et al (show 3 more authors)
(2023)
A Universal Bleeding Risk Score in Native and Allograft Kidney Biopsies: A French Nationwide Cohort Study.
JOURNAL OF CLINICAL MEDICINE, 12 (10).
3527-.
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Abstract
<h4>Background</h4>The risk of bleeding after percutaneous biopsy in kidney transplant recipients is usually low but may vary. A pre-procedure bleeding risk score in this population is lacking.<h4>Methods</h4>We assessed the major bleeding rate (transfusion, angiographic intervention, nephrectomy, hemorrhage/hematoma) at 8 days in 28,034 kidney transplant recipients with a kidney biopsy during the 2010-2019 period in France and compared them to 55,026 patients with a native kidney biopsy as controls.<h4>Results</h4>The rate of major bleeding was low (angiographic intervention: 0.2%, hemorrhage/hematoma: 0.4%, nephrectomy: 0.02%, blood transfusion: 4.0%). A new bleeding risk score was developed (anemia = 1, female gender = 1, heart failure = 1, acute kidney failure = 2 points). The rate of bleeding varied: 1.6%, 2.9%, 3.7%, 6.0%, 8.0%, and 9.2% for scores 0 to 5, respectively, in kidney transplant recipients. The ROC AUC was 0.649 (0.634-0.664) in kidney transplant recipients and 0.755 (0.746-0.763) in patients who had a native kidney biopsy (rate of bleeding: from 1.2% for score = 0 to 19.2% for score = 5).<h4>Conclusions</h4>The risk of major bleeding is low in most patients but indeed variable. A new universal risk score can be helpful to guide the decision concerning kidney biopsy and the choice of inpatient vs. outpatient procedure both in native and allograft kidney recipients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | biopsy, bleeding, score, native kidney, kidney graft, epidemiology |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 Jul 2023 15:12 |
| Last Modified: | 07 Jul 2023 15:12 |
| DOI: | 10.3390/jcm12103527 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3171552 |
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