Organ and Function Preservation in Gastrointestinal Malignancies

Sur, R, Than, NW ORCID: 0000-0003-4991-5431, Taggar, A, Sripadam, R and Myint, A Sun (2023) Organ and Function Preservation in Gastrointestinal Malignancies. CLINICAL ONCOLOGY, 35 (8). pp. 524-532.

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Abstract

Radiation plays an important role in organ preservation for gastrointestinal malignancies, with a watch and wait strategy enabling surgery to be avoided in patients who are not suitable or who are refusing surgery. Brachytherapy boost allows the radiation dose to be escalated, which plays a pivotal role in the successful outcome of achieving organ preservation. Here we describe the role of brachytherapy in two common gastrointestinal malignancies (oesophagus and rectum). Their indications and how the brachytherapy procedures are carried out, together with the dose and fractionation commonly used are discussed. The use of brachytherapy needs to be included in the training curriculum at all academic centres so that its use is developed by the newer generation of radiation oncologists. Its current non-use due to bias, lack of training and availability is no longer justified, given the overwhelming published evidence for the role of brachytherapy to improve organ preservation for both radical treatment and palliation in gastrointestinal malignancies.

Item Type:	Article
Uncontrolled Keywords:	Brachytherapy, contact X-ray brachytherapy, HDR, oesophageal cancer, rectal cancer
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	19 Jul 2023 13:11
Last Modified:	12 Aug 2023 15:56
DOI:	10.1016/j.clon.2023.06.012
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3171603