Tyagi, Gunjan, Greenfield, Jake L, Jones, Beatrice E, Sharratt, William N 
ORCID: 0000-0003-2148-8423, Khan, Kasim, Seddon, Dale, Malone, Lorna A, Cowieson, Nathan, Evans, Rachel C, Fuchter, Matthew J et al (show 1 more authors)
(2022)
Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles.
JACS AU, 2 (12).
pp. 2670-2677.
Abstract
The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from <i>E</i>-PS (<i>trans</i>) to <i>Z</i>-PS (<i>cis</i>), which transforms oblate ellipsoidal micelles into smaller, spherical micelles with larger shell thickness. Doping PS with CTAB resulted in mixed micelle formation at all stoichiometries and conditions investigated; employing selectively deuterated PS, a monotonic variation in scattering length density and dimensions of the micellar core and shell is observed for all contrasts. The concentration- and irradiance-dependence of the <i>E</i> to <i>Z</i> configurational transition was established in both neat and mixed micelles. A liposome dye release assay establishes the enhanced efficacy of photosurfactants at membrane disruption, with <i>E</i>-PS exhibiting a 4-fold and <i>Z</i>-PS a 10-fold increase in fluorescence signal with respect to pure CTAB. Our findings pave the way for external triggering and modulation of the wide range of CTAB-based biomedical and material applications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | photosurfactant, CTAB, arylazopyrazole, micelle, SANS, SAXS, liposome |
| Divisions: | Faculty of Science and Engineering > School of Engineering |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 25 Jul 2023 11:39 |
| Last Modified: | 25 Jul 2023 11:39 |
| DOI: | 10.1021/jacsau.2c00453 |
| Open Access URL: | https://pubs.acs.org/doi/full/10.1021/jacsau.2c004... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3171887 |
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