De Neck, Simon, Penrice-Randal, Rebekah 
ORCID: 0000-0002-0653-2097, Clark, Jordan J, Sharma, Parul, Bentley, Eleanor G, Kirby, Adam, Mega, Daniele F, Han, Ximeng, Owen, Andrew ORCID: 0000-0002-9819-7651, Hiscox, Julian A ORCID: 0000-0002-6582-0275 et al (show 2 more authors)
(2023)
The Stereotypic Response of the Pulmonary Vasculature to Respiratory Viral Infections: Findings in Mouse Models of SARS-CoV-2, Influenza A and Gammaherpesvirus Infections.
Viruses, 15 (8).
p. 1637.
Abstract
<jats:p>The respiratory system is the main target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 19 (COVID-19) where acute respiratory distress syndrome is considered the leading cause of death. Changes in pulmonary blood vessels, among which an endothelialitis/endotheliitis has been particularly emphasized, have been suggested to play a central role in the development of acute lung injury. Similar vascular changes are also observed in animal models of COVID-19. The present study aimed to determine whether the latter are specific for SARS-CoV-2 infection, investigating the vascular response in the lungs of mice infected with SARS-CoV-2 and other respiratory viruses (influenza A and murine gammaherpesvirus) by in situ approaches (histology, immunohistology, morphometry) combined with RNA sequencing and bioinformatic analysis. Non-selective recruitment of monocytes and T and B cells from larger muscular veins and arteries was observed with all viruses, matched by a comparable transcriptional response. There was no evidence of endothelial cell infection in any of the models. Both the morphological investigation and the transcriptomics approach support the interpretation that the lung vasculature in mice mounts a stereotypic response to alveolar and respiratory epithelial damage. This may have implications for the treatment and management of respiratory disease in humans.</jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | severe acute respiratory syndrome coronavirus 2, influenza A virus, murine gammaherpesvirus 68, mouse models, lung, vasculitis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology Faculty of Health and Life Sciences > Research and Impact Directorate |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 01 Aug 2023 10:08 |
| Last Modified: | 13 Sep 2023 12:29 |
| DOI: | 10.3390/v15081637 |
| Open Access URL: | https://doi.org/10.3390/v15081637 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3172011 |
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