An international multidisciplinary consensus statement on MAFLD and the risk of CVD.

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Zhou, Xiao-Dong ORCID: 0000-0002-8534-0818, Targher, Giovanni, Byrne, Christopher D, Somers, Virend, Kim, Seung Up, Chahal, C Anwar A, Wong, Vincent Wai-Sun, Cai, Jingjing, Shapiro, Michael D, Eslam, Mohammed et al (show 38 more authors) , Steg, Philippe Gabriel, Sung, Ki-Chul, Misra, Anoop, Li, Jian-Jun, Brotons, Carlos, Huang, Yuli, Papatheodoridis, George V, Sun, Aijun, Yilmaz, Yusuf, Chan, Wah Kheong, Huang, Hui, Méndez-Sánchez, Nahum, Alqahtani, Saleh A ORCID: 0000-0003-2017-3526, Cortez-Pinto, Helena, Lip, Gregory YH ORCID: 0000-0002-7566-1626, de Knegt, Robert J, Ocama, Ponsiano, Romero-Gomez, Manuel, Fudim, Marat ORCID: 0000-0002-8671-7007, Sebastiani, Giada, Son, Jang Won, Ryan, John D, Ikonomidis, Ignatios, Treeprasertsuk, Sombat, Pastori, Daniele, Lupsor-Platon, Monica ORCID: 0000-0001-7918-1956, Tilg, Herbert, Ghazinyan, Hasmik, Boursier, Jerome, Hamaguchi, Masahide, Nguyen, Mindie H, Fan, Jian-Gao, Goh, George Boon-Bee, Al Mahtab, Mamun, Hamid, Saeed, Perera, Nilanka ORCID: 0000-0003-0154-1864, George, Jacob and Zheng, Ming-Hua ORCID: 0000-0003-4984-2631 (2023) An international multidisciplinary consensus statement on MAFLD and the risk of CVD. Hepatology international, 17 (4). pp. 773-791.

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Abstract

<h4>Background</h4>Fatty liver disease in the absence of excessive alcohol consumption is an increasingly common condition with a global prevalence of ~ 25-30% and is also associated with cardiovascular disease (CVD). Since systemic metabolic dysfunction underlies its pathogenesis, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has been proposed for this condition. MAFLD is closely intertwined with obesity, type 2 diabetes mellitus and atherogenic dyslipidemia, which are established cardiovascular risk factors. Unlike CVD, which has received attention in the literature on fatty liver disease, the CVD risk associated with MAFLD is often underestimated, especially among Cardiologists.<h4>Methods and results</h4>A multidisciplinary panel of fifty-two international experts comprising Hepatologists, Endocrinologists, Diabetologists, Cardiologists and Family Physicians from six continents (Asia, Europe, North America, South America, Africa and Oceania) participated in a formal Delphi survey and developed consensus statements on the association between MAFLD and the risk of CVD. Statements were developed on different aspects of CVD risk, ranging from epidemiology to mechanisms, screening, and management.<h4>Conculsions</h4>The expert panel identified important clinical associations between MAFLD and the risk of CVD that could serve to increase awareness of the adverse metabolic and cardiovascular outcomes of MAFLD. Finally, the expert panel also suggests potential areas for future research.

Item Type:	Article
Uncontrolled Keywords:	Humans, Liver Diseases, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Consensus, Asia, Non-alcoholic Fatty Liver Disease
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	09 Aug 2023 15:14
Last Modified:	09 Aug 2023 15:14
DOI:	10.1007/s12072-023-10543-8
Open Access URL:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3172128