Antimicrobial resistance in neonates with suspected sepsis

Yadav, SK, Agrawal, SK, Singh, SK, Giri, A, Singh, GK, Ghimire, R, Stewart, AG ORCID: 0000-0002-4931-5340, Show, KL and Moses, FL (2021) Antimicrobial resistance in neonates with suspected sepsis. PUBLIC HEALTH ACTION, 11 (1). pp. 6-12.

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Official URL: http://dx.doi.org/10.5588/pha.21.0038

Abstract

<h4>Setting</h4>Nobel Medical College and Teaching Hospital, Biratnagar, Nepal.<h4>Objective</h4>To determine the pattern of antimicrobial resistance and hospital exit outcomes in neonates with suspected sepsis in a tertiary neonatal intensive care unit (NICU).<h4>Design</h4>This hospital-based cohort study was conducted to follow patients from January to December 2019. All identified cases of suspected sepsis were enlisted from hospital records.<h4>Results</h4>Sepsis was suspected in 177 (88%) of the 200 cases admitted in the NICU; 52 (29%) were culture-positive. <i>Pseudomonas</i> was the predominant organism isolated (<i>n</i> = 40; 78%), followed by coagulase negative <i>staphylococcus</i> (<i>n</i> = 12, 23%). Nine (17%) of the 52 isolates were resistant to the Access and Watch group of antibiotics, including some resistance to Reserve group drugs such as imipenem and linezolid. Most treated cases (<i>n</i> = 170, 96%) improved, although 7 (4%) left against medical advice.<h4>Conclusion</h4>Most of the pathogens were resistant to WHO Access and Watch antibiotics and occasional resistance was observed to Reserve group drugs. Most sepsis was caused by Gram-negative bacilli. Improving turnaround times for antibiotic sensitivity testing using point-of-care testing, and a greater yield of culture-positive results are needed to enhance the management of neonatal sepsis.

Item Type:	Article
Uncontrolled Keywords:	antimicrobial resistance, neonatal sepsis, NICU
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health
Depositing User:	Symplectic Admin
Date Deposited:	10 Aug 2023 13:50
Last Modified:	17 Mar 2024 17:20
DOI:	10.5588/pha.21.0038
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3172131