Antithrombotic treatment pattern in newly diagnosed atrial fibrillation patients and 2-year follow-up results for dabigatran-treated patients in the Africa/Middle-East Region: Phase II results from the GLORIA-AF registry program.

Azar, Rabih R, Ragy, Hany I, Kozan, Omer, El Khuri, Maurice, Bazergani, Nooshin, Marler, Sabrina, Teutsch, Christine ORCID: 0000-0002-8494-2876, Ibrahim, Mohamed, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Huisman, Menno V (2021) Antithrombotic treatment pattern in newly diagnosed atrial fibrillation patients and 2-year follow-up results for dabigatran-treated patients in the Africa/Middle-East Region: Phase II results from the GLORIA-AF registry program. International journal of cardiology. Heart & vasculature, 34. 100763-.

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Official URL: http://dx.doi.org/10.1016/j.ijcha.2021.100763

Abstract

<h4>Background</h4>Data on the epidemiology and treatment of atrial fibrillation in the Africa/Middle East region are limited, and the use of novel oral anticoagulants and their effectiveness in real-world clinical practice has not been evaluated.<h4>Methods and results</h4>This study used prospectively collected data from the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation (GLORIA-AF) to describe anticoagulant use and outcomes in Africa and the Middle East. Baseline characteristics of patients newly diagnosed with nonvalvular atrial fibrillation from Lebanon (242 patients, 40.3%), Saudi Arabia (236 patients, 39.3%), United Arab Emirates (87 patients, 14.5%), and South Africa (35 patients, 5.8%) were described, and clinical outcomes were investigated for all patients in this region who received dabigatran.In newly diagnosed patients (having a diagnosis within the last three months) with nonvalvular atrial fibrillation in Africa and the Middle East, the observed uptake of non-vitamin K oral anticoagulants was high in the first years following their availability; dabigatran was the most commonly used antithrombotic agent (314/600 patients), and only 1.5% of patients did not receive any antithrombotic therapy. Use of dabigatran was associated with a high persistence rate (>88% at 24 months) and low incidence rates of stroke, myocardial infarction, major bleeding, and all-cause mortality after 2 years of follow-up.<h4>Conclusions</h4>Data from GLORIA-AF reveal a change in the landscape for stroke prevention in the AME region, and the results were consistent with those observed in the global GLORIA-AF registry, as well as those of randomized clinical trials.<b>Clinical Trial Registration:</b> NCT01937377 (https://clinicaltrials.gov/ct2/show/NCT01937377).

Item Type:	Article
Uncontrolled Keywords:	Anticoagulant, Atrial fibrillation, NOACs
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	10 Aug 2023 13:48
Last Modified:	10 Aug 2023 13:48
DOI:	10.1016/j.ijcha.2021.100763
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3172134