Nawaz, Hamed, Mujahid, , Khan, Sher Alam, Bibi, Farhana, Waqas, Ahmed 
ORCID: 0000-0002-3772-194X, Bari, Abdul, Fardous, , Khan, Niamatullah, Muhammad, Nazif, Khan, Amjad et al (show 10 more authors)
(2023)
Biallelic Variants in Seven Different Genes Associated with Clinically Suspected Bardet-Biedl Syndrome.
GENES, 14 (5).
1113-.
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Biallelic Variants in Seven Different Genes Associated with Clinically Suspected Bardet-Biedl Syndrome.pdf - Open Access published version Download (2MB) | Preview |
Abstract
Bardet-Biedl syndrome (BBS) is a rare clinically and genetically heterogeneous autosomal recessive multi-systemic disorder with 22 known genes. The primary clinical and diagnostic features include six different hallmarks, such as rod-cone dystrophy, learning difficulties, renal abnormalities, male hypogonadism, post-axial polydactyly, and obesity. Here, we report nine consanguineous families and a non-consanguineous family with several affected individuals presenting typical clinical features of BBS. In the present study, 10 BBS Pakistani families were subjected to whole exome sequencing (WES), which revealed novel/recurrent gene variants, including a homozygous nonsense mutation (c.94C>T; p.Gln32Ter) in the <i>IFT27</i> (NM_006860.5) gene in family A, a homozygous nonsense mutation (c.160A>T; p.Lys54Ter) in the <i>BBIP1</i> (NM_001195306.1) gene in family B, a homozygous nonsense variant (c.720C>A; p.Cys240Ter) in the <i>WDPCP</i> (NM_015910.7) in family C, a homozygous nonsense variant (c.505A>T; p.Lys169Ter) in the <i>LZTFL1</i> (NM_020347.4) in family D, pathogenic homozygous 1 bp deletion (c.775delA; p.Thr259Leufs*21) in the <i>MKKS</i>/<i>BBS5</i> (NM_170784.3) gene in family E, a pathogenic homozygous missense variant (c.1339G>A; p.Ala447Thr) in <i>BBS1</i> (NM_024649.4) in families F and G, a pathogenic homozygous donor splice site variant (c.951+1G>A; p?) in <i>BBS1</i> (NM_024649.4) in family H, a pathogenic bi-allelic nonsense variant in <i>MKKS</i> (NM_170784.3) (c.119C>G; p.Ser40*) in family I, and homozygous pathogenic frameshift variants (c.196delA; p.Arg66Glufs*12) in <i>BBS5</i> (NM_152384.3) in family J. Our findings extend the mutation and phenotypic spectrum of four different types of ciliopathies causing BBS and also support the importance of these genes in the development of multi-systemic human genetic disorders.
| Item Type: | Article |
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| Uncontrolled Keywords: | ciliopathy, Bardet-Biedl syndrome, IFT27, BBIP1, WDPCP, LZTFL1, MKKS, BBS1, BBS5, polydactyly, obesity, intellectual disability |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Aug 2023 14:56 |
| Last Modified: | 21 Aug 2023 19:24 |
| DOI: | 10.3390/genes14051113 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3172159 |
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