Khanom, Anjum Aarifa, Franceschini, Paulo Roberto, Lane, Steven, Osman-Farah, Jibril and Macerollo, Antonella 
ORCID: 0000-0003-4322-2706
(2023)
Bilateral globus pallidus internus (GPi) deep brain stimulation for cervical dystonia: Effects on motor and non-motor symptoms within 5 years follow.
Journal of the neurological sciences, 452.
p. 120752.
Abstract
<h4>Background</h4>Cervical Dystonia ("CD") is a movement disorder characterised by sustained muscle contractions in the neck, causing involuntary posturing. Deep brain stimulation ("DBS") of the globus pallidal internus (GPi) is advanced treatment for pharmaco-refractory patients. As CD is a rare disease, cohort studies are often limited to patients of heterogenous disease profile, small sample size or short follow-up. This study firstly aimed to measure the efficacy of GPi-DBS on motor and non-motor symptoms of CD. A secondary aim was to evaluate if clinical factors - such as age, disease duration and baseline disease severity - influence variability of motor outcomes.<h4>Methods</h4>37 idiopathic CD patients were recruited from movement disorders clinics at The Walton NHS Foundation Trust, Liverpool, UK. Patients were assessed pre-operatively, and 1 year, 3 years and 5 years post-operatively with the following clinical scales: Toronto Western Spasmodic Torticollis Rating Scale ("TWSTRS"), Hospital Anxiety and Depression Scale and EuroQuol-5D.<h4>Results</h4>GPI-DBS significantly improved overall TWSTRS scores by 57% from baseline to 5Y FU (p < 0.001). It also significantly improved TWSTRS severity, disability, and pain sub-scores by 72%, 59% and 46% respectively. We did not find a significant improvement in mood or quality of life scores at 5 years. Similarly, clinical factors at baseline did not correlate with variability in motor outcome.<h4>Conclusion</h4>We concluded that GPi-DBS is an effective treatment for motor symptoms and pain in CD. There was limited effect on mood and QoL, and no clinical predictive factors of outcome were identified.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Globus Pallidus, Humans, Torticollis, Pain, Treatment Outcome, Deep Brain Stimulation, Quality of Life |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 22 Aug 2023 09:41 |
| Last Modified: | 25 Sep 2023 20:33 |
| DOI: | 10.1016/j.jns.2023.120752 |
| Open Access URL: | https://doi.org/10.1016/j.jns.2023.120752 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3172287 |
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