Ashton, PM, Thanh, LT, Trieu, PN, Van Anh, D, Trinh, NM, Beardsley, J, Kibengo, F, Chierakul, W, Dance, DAB, Rattanavong, S et al (show 14 more authors)
(2019)
Three phylogenetic groups have driven the recent population expansion of <i>Cryptococcus neoformans</i>.
NATURE COMMUNICATIONS, 10 (1).
2035-.
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Abstract
Cryptococcus neoformans (C. neoformans var. grubii) is an environmentally acquired pathogen causing 181,000 HIV-associated deaths each year. We sequenced 699 isolates, primarily C. neoformans from HIV-infected patients, from 5 countries in Asia and Africa. The phylogeny of C. neoformans reveals a recent exponential population expansion, consistent with the increase in the number of susceptible hosts. In our study population, this expansion has been driven by three sub-clades of the C. neoformans VNIa lineage; VNIa-4, VNIa-5 and VNIa-93. These three sub-clades account for 91% of clinical isolates sequenced in our study. Combining the genome data with clinical information, we find that the VNIa-93 sub-clade, the most common sub-clade in Uganda and Malawi, was associated with better outcomes than VNIa-4 and VNIa-5, which predominate in Southeast Asia. This study lays the foundation for further work investigating the dominance of VNIa-4, VNIa-5 and VNIa-93 and the association between lineage and clinical phenotype.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Cryptococcus neoformans, AIDS-Related Opportunistic Infections, Cryptococcosis, Antifungal Agents, Treatment Outcome, Incidence, Phylogeny, Genome, Fungal, Uganda, Malawi, Laos, Thailand, Vietnam, Clinical Trials as Topic, Whole Genome Sequencing |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 15 Sep 2023 10:59 |
| Last Modified: | 13 Oct 2023 21:14 |
| DOI: | 10.1038/s41467-019-10092-5 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3172784 |
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