Rigby, Jake, Fisher, Peter 
ORCID: 0000-0002-7388-720X, Cherry, Gemma, Stuart, Taylor and Temple, James ORCID: 0000-0001-5351-5196
(2021)
A clinical significance analysis of manualised psychological interventions for obsessive-compulsive disorder.
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Abstract
<jats:sec id="S2056472421007584_sec_a1"><jats:title>Aims</jats:title><jats:p>To conduct an individual patient data meta-analysis of randomised controlled trials (RCTs) of manualised psychological treatments for obsessive-compulsive disorder (OCD), and examine the differential efficacy of psychological treatments by treatment type and format.</jats:p></jats:sec><jats:sec id="S2056472421007584_sec_a2"><jats:title>Background</jats:title><jats:p>Previous meta-analyses conclude that efficacious psychological treatments for OCD exist. However, determining the efficacy of psychological treatments requires multiple forms of assessment across a range of indexes, yet most previous meta-analyses in OCD are based solely on effect sizes.</jats:p></jats:sec><jats:sec id="S2056472421007584_sec_a3"><jats:title>Method</jats:title><jats:p>We evaluated treatment efficacy across 24 RCTs (n = 1,667) by conducting clinical significance analyses (using standardised Jacobson methodology) and standardised mean difference within-group effect-size analyses. Outcomes were Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores, evaluated at post-treatment and follow-up (3-6 months post-treatment).</jats:p></jats:sec><jats:sec id="S2056472421007584_sec_a4"><jats:title>Result</jats:title><jats:p>Post-treatment, there was a large significant within-group effect size for treated patients (g = 1.28) and a small significant effect size for controls (g = 0.30). At follow-up, large within-group effect sizes were found for both treated patients (g = 1.45) and controls (g = 0.90). Clinical significance analyses indicated that treated patients were significantly more likely than controls to recover following an intervention, but recovery rates were low; post-intervention, only 32% of treated patients and 3% of controls recovered; rising to 38% and 21% respectively at follow-up. Regardless of allocation, only approximately 20% of patients were asymptomatic at follow-up. Across the different analysis methods, individual cognitive therapy (CT) was the most effective intervention, followed by group CT plus exposure and response prevention. Self-help interventions were generally less effective.</jats:p></jats:sec><jats:sec id="S2056472421007584_sec_a5"><jats:title>Conclusion</jats:title><jats:p>Reliance on aggregated within-group effect sizes may lead to overestimation of the efficacy of psychological treatments for OCD. More research is needed to determine the most effective treatment type and format for patients with OCD.</jats:p></jats:sec>
| Item Type: | Conference or Workshop Item (Unspecified) |
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| Uncontrolled Keywords: | Clinical Research, Serious Mental Illness, Clinical Trials and Supportive Activities, Mental Health, Comparative Effectiveness Research, 6 Evaluation of treatments and therapeutic interventions, 6.6 Psychological and behavioural, Mental health, 3 Good Health and Well Being |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Sep 2023 11:22 |
| Last Modified: | 15 Mar 2024 03:59 |
| DOI: | 10.1192/bjo.2021.758 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3172899 |
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