Neural correlates of naturalistic single-trial appetitive conditioning

Davies-Owen, Jennifer A, Stancak, Andrej, Giesbrecht, Timo, Thomas, Anna, Kirkham, Tim C and Roberts, Carl A ORCID: 0000-0003-4275-601X (2023) Neural correlates of naturalistic single-trial appetitive conditioning. Physiology & Behavior, 271. p. 114350.

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Official URL: http://dx.doi.org/10.1016/j.physbeh.2023.114350

Abstract

<h4>Background</h4>Prior research suggests naturalistic single-trial appetitive conditioning may be a potent phenomenon in humans, capable of modulating both motivation and attention. In this study, we aimed to characterise the neural correlates of this phenomenon using functional Magnetic Resonance Imaging (fMRI) paradigms METHODS: Twenty-three healthy adults (12 males) underwent conditioning during which they ate a novel 3D object made from white chocolate (CS+) and handled a similar object made from plastic (CS-). Brain activity was recorded before and after conditioning during a passive viewing paradigm RESULTS: A naturalistic CS+ was rated as more highly craved, better-liked and elicited greater expectancies for chocolate than the CS- after conditioning. An exploration of the interaction between time (pre- and post-conditioning) and CS type (CS+, CS-) during the passive viewing task suggested enhanced activation from pre- to post-conditioning in the right superior frontal gyrus (R.SFG) in response to the CS-.<h4>Conclusion</h4>Results reveal neural correlates of single-trial appetitive conditioning and highlight a possible role of response inhibition during learning about non-rewards, perhaps optimizing motivated behaviour. These findings contribute to our understanding of the neural mechanisms underpinning rapid reward and non-reward learning, and may inform development of behavioural interventions for reward-driven overeating.

Item Type:	Article
Uncontrolled Keywords:	Appetitive conditioning, Single-trial conditioning, Food cue reactivity, Food craving, fMRI
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health
Depositing User:	Symplectic Admin
Date Deposited:	22 Sep 2023 09:55
Last Modified:	24 Oct 2023 18:46
DOI:	10.1016/j.physbeh.2023.114350
Open Access URL:	https://doi.org/10.1016/j.physbeh.2023.114350
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3172970