Discovery of 42 genome-wide significant loci associated with dyslexia

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Doust, Catherine, Fontanillas, Pierre, Eising, Else, Gordon, Scott D, Wang, Zhengjun, Alagöz, Gökberk, Molz, Barbara, Aslibekyan, Stella, Auton, Adam, Babalola, Elizabeth et al (show 137 more authors) , Bell, Robert K, Bielenberg, Jessica, Bryc, Katarzyna, Bullis, Emily, Coker, Daniella, Partida, Gabriel Cuellar, Dhamija, Devika, Das, Sayantan, Elson, Sarah L, Filshtein, Teresa, Fletez-Brant, Kipper, Freyman, Will, Gandhi, Pooja M, Heilbron, Karl, Hicks, Barry, Hinds, David A, Jewett, Ethan M, Jiang, Yunxuan, Kukar, Katelyn, Lin, Keng-Han, Lowe, Maya, McCreight, Jey, McIntyre, Matthew H, Micheletti, Steven J, Moreno, Meghan E, Mountain, Joanna L, Nandakumar, Priyanka, Noblin, Elizabeth S, O’Connell, Jared, Petrakovitz, Aaron A, Poznik, G David, Schumacher, Morgan, Shastri, Anjali J, Shelton, Janie F, Shi, Jingchunzi, Shringarpure, Suyash, Tran, Vinh, Tung, Joyce Y, Wang, Xin, Wang, Wei, Weldon, Catherine H, Wilton, Peter, Hernandez, Alejandro, Wong, Corinna, Tchakouté, Christophe Toukam, Abbondanza, Filippo, Allegrini, Andrea G, Andlauer, Till FM, Barr, Cathy L, Bernard, Manon, Blokland, Kirsten, Bonte, Milene, Boomsma, Dorret I, Bourgeron, Thomas, Brandeis, Daniel, Carreiras, Manuel, Ceroni, Fabiola, Csépe, Valéria, Dale, Philip S, de Jong, Peter F, Démonet, Jean Francois, de Zeeuw, Eveline L, Feng, Yu, Franken, Marie-Christine J, Gerritse, Margot, Gialluisi, Alessandro, Guger, Sharon L, Hayiou-Thomas, Marianna E, Hernández-Cabrera, Juan, Hottenga, Jouke-Jan, Hulme, Charles, Jansen, Philip R, Kere, Juha, Kerr, Elizabeth N, Koomar, Tanner, Landerl, Karin, Leonard, Gabriel T, Liao, Zhijie, Lovett, Maureen W, Lyytinen, Heikki, Martinelli, Angela, Maurer, Urs, Michaelson, Jacob J, Mirza-Schreiber, Nazanin, Moll, Kristina, Morgan, Angela T, Müller-Myhsok, Bertram ORCID: 0000-0002-0719-101X, Newbury, Dianne F, Nöthen, Markus M, Paus, Tomas, Pausova, Zdenka, Pennell, Craig E, Plomin, Robert J, Price, Kaitlyn M, Ramus, Franck, Reilly, Sheena, Richer, Louis, Rimfeld, Kaili, Schulte-Körne, Gerd, Shapland, Chin Yang, Simpson, Nuala H, Snowling, Margaret J, Stein, John F, Strug, Lisa J, Tiemeier, Henning, Tomblin, J Bruce, Truong, Dongnhu T, van Bergen, Elsje, van der Schroeff, Marc P, Van Donkelaar, Marjolein, Verhoef, Ellen, Wang, Carol A, Watkins, Kate E, Whitehouse, Andrew JO, Wigg, Karen G, Wilkinson, Margaret, Zhu, Gu, Pourcain, Beate St, Francks, Clyde, Marioni, Riccardo E, Zhao, Jingjing, Paracchini, Silvia, Talcott, Joel B, Monaco, Anthony P, Stein, John F, Gruen, Jeffrey R, Olson, Richard K, Willcutt, Erik G, DeFries, John C, Pennington, Bruce F, Smith, Shelley D, Wright, Margaret J, Martin, Nicholas G, Auton, Adam, Bates, Timothy C, Fisher, Simon E and Luciano, Michelle (2022) Discovery of 42 genome-wide significant loci associated with dyslexia. Nature Genetics, 54 (11). pp. 1621-1629.

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Abstract

<jats:title>Abstract</jats:title><jats:p>Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.</jats:p>

Item Type:	Article
Uncontrolled Keywords:	23andMe Research Team, Quantitative Trait Working Group of the GenLang Consortium, Humans, Dyslexia, Language, Reading, Adult, Child, Genome-Wide Association Study, Asian People
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health
Depositing User:	Symplectic Admin
Date Deposited:	26 Sep 2023 09:03
Last Modified:	18 Mar 2024 03:31
DOI:	10.1038/s41588-022-01192-y
Open Access URL:	https://doi.org/10.1038/s41588-022-01192-y
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3173048