Association between the accumulation of elevated serum γ-glutamyltransferase level and risk of atrial fibrillation: a nationwide cohort study.

Jeon, Won Kyeong, Lee, So-Ryoung, Han, Kyung-Do, Choi, Eue-Keun, Oh, Seil and Lip, Gregory YH ORCID: 0000-0002-7566-1626 (2023) Association between the accumulation of elevated serum γ-glutamyltransferase level and risk of atrial fibrillation: a nationwide cohort study. Scientific reports, 13 (1). 13771-.

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Official URL: http://dx.doi.org/10.1038/s41598-023-40689-2

Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia. The association between AF and γ-Glutamyltransferase (GGT) was not fully established. This study demonstrated the independent association of cumulative GGT score and AF incidence with the dose-response relationship. Using the Korean National Health Insurance Corporation database, adult subjects who had 4 consecutive annual health examinations from 2009 to 2012 were enrolled. A cumulative GGT score was calculated as the cumulative number of the highest GGT quartile amongst four examinations (0-4 times). A multivariable Cox proportional hazards regression analysis was performed. Among a total of 3,500,847 people included, AF was developed in 27,752 people (0.793%) during a median of 8.0 years of follow up. The incidence rate of AF and adjusted hazard ratio were increased by a stepwise manner in the higher quartile group and cumulative GGT score group. In subgroup analysis, this trend was more prominent in the elderly, people without hypertension, non-obese people, and people without any four comorbidities (diabetes mellitus, hypertension, dyslipidemia, and obesity). Our results suggest multiple accumulation of elevated GGT levels in health examination might be a useful marker for risk stratification of AF development, especially in the elderly and healthy population.

Item Type:	Article
Uncontrolled Keywords:	Humans, Atrial Fibrillation, Hypertension, Obesity, gamma-Glutamyltransferase, Cohort Studies, Adult, Aged, Cardiac Conduction System Disease
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	26 Sep 2023 13:33
Last Modified:	26 Sep 2023 13:34
DOI:	10.1038/s41598-023-40689-2
Open Access URL:	https://doi.org/10.1038/s41598-023-40689-2
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3173070