Huang, Xin, Liu, Jun, Qi, Lu, Adachi, Jonathan D, Wu, Jing, Li, Ziyi, Meng, Qiong, Li, Guowei and Lip, Gregory YH 
ORCID: 0000-0002-7566-1626
(2022)
Birth Weight and the Risk of Cardiovascular Outcomes: A Report From the Large Population-Based UK Biobank Cohort Study.
FRONTIERS IN CARDIOVASCULAR MEDICINE, 9.
827491-.
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Abstract
<h4>Background</h4>Birth weight has been reported to be associated with the risk of incident cardiovascular disease (CVD); however, the relationship remains inconclusive. Here, we aimed to prospectively assess the associations between birth weight and CVD risk using the data from UK Biobank, a large-scale, prospective cohort study.<h4>Methods</h4>We included 270,297 participants who were free of CVD at baseline and reported their birth weight for analyses. The primary outcome was incident CVD. Hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were calculated using Cox proportional hazards models adjusted for potential confounding variables.<h4>Results</h4>During a median follow-up of 8.07 years (IQR: 7.4-8.7 years), 10,719 incident CVD events were recorded. The HRs for low birth weight vs. normal birth weight (2.5-4.0 kg) were 1.23 (95% CI: 1.09-1.38) for risk of incident CVD, 1.52 (95% CI: 1.18-1.95) for stroke, 1.33 (95% CI: 1.07-1.64) for myocardial infarction, and 1.15 (95% CI: 1.01-1.32) for CHD. For the ones with low birth weight, the risk of CVD is reduced by 11% for every kilogram of birth weight gain. The association of low birth weight with CVD was stronger among those younger than 55 years (<i>p</i> = 0.001). No association between high birth weight and risk of cardiovascular outcomes was found.<h4>Conclusion</h4>Low birth weight was associated with an increased risk of cardiovascular events. These findings highlight the longstanding consequence of low birth weight on cardiovascular system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | epidemiology, birth weight, cardiovascular disease, association, cohort |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 26 Sep 2023 14:13 |
| Last Modified: | 26 Sep 2023 14:13 |
| DOI: | 10.3389/fcvm.2022.827491 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173078 |
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