Zhang, Nan, Wang, Yueying, Chen, Ziliang, Liu, Daiqi, Tse, Gary, Korantzopoulos, Panagiotis, Letsas, Konstantinos P, Goudis, Christos A, Lip, Gregory YH 
ORCID: 0000-0002-7566-1626, Li, Guangping et al (show 2 more authors)
(2022)
Circulating Vitamin D Concentrations and Risk of Atrial Fibrillation: A Mendelian Randomization Study Using Non-deficient Range Summary Statistics.
FRONTIERS IN NUTRITION, 9.
842392-.
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Abstract
<h4>Background and aims</h4>Vitamin D deficiency is a common disorder and has been linked with atrial fibrillation (AF) in several observational studies, although the causal relationships remain unclear. We conducted a Mendelian randomization (MR) analysis to determine the causal association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and AF.<h4>Methods and results</h4>The analyses were performed using summary statistics obtained for single-nucleotide polymorphisms (SNPs) identified from large genome-wide association meta-analyses conducted on serum 25(OH)D (<i>N</i> = 79,366) and AF (<i>N</i> = 1,030,836). Six SNPs related to serum 25(OH)D were used as instrumental variables. The association between 25(OH)D and AF was estimated using both the fixed-effect and random-effects inverse variance weighted (IVW) method. The MR analyses found no evidence to support a causal association between circulating 25(OH)D level and risk of AF using random-effects IVW (odds ratio per unit increase in log 25(OH)D = 1.003, 95% CI, 0.841-1.196; <i>P</i> = 0.976) or fixed-effect IVW method (OR = 1.003, 95% CI, 0.876-1.148; <i>P</i> = 0.968). Sensitivity analyses yielded similar results. No heterogeneity and directional pleiotropy were detected.<h4>Conclusion</h4>Using summary statistics, this MR study suggests that genetically predicted circulating vitamin D concentrations, especially for a non-deficient range, were not causally associated with AF in the general population. Future studies using non-linear design and focusing on the vitamin D deficiency population are needed to further evaluate the causal effect of vitamin D concentrations on AF.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | vitamin D, Mendelian randomization, single-nucleotide polymorphisms, causal association, atrial fibrillation |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 28 Sep 2023 09:16 |
| Last Modified: | 28 Sep 2023 09:16 |
| DOI: | 10.3389/fnut.2022.842392 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173143 |
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