Clinical Features Associated with 'Normal Range' Fibrin D-Dimer Levels in Atrial Fibrillation Patients with Left Atrial Thrombus

Bai, Ying, Luo, Si-Qing, Liu, Si-Tong, Gong, Ling, Zhong, Peng, Wang, Zhen-Zhou, Lip, Gregory YH ORCID: 0000-0002-7566-1626, Zou, Yi-Xi and Guo, Wei-Hua (2022) Clinical Features Associated with 'Normal Range' Fibrin D-Dimer Levels in Atrial Fibrillation Patients with Left Atrial Thrombus. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 28. 10760296221133380-.

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Official URL: http://dx.doi.org/10.1177/10760296221133380

Abstract

<h4>Background</h4>Left atrial thrombus (LAT) often complicates with atrial fibrillation (AF). The evidence whether fibrin D-dimer levels could be used as a predictive biomarker for LAT is contradictory. This study firstly investigated the relationship between 'normal range' D-dimer and prevalent LAT. Second, we explored factors contributing to normal D-dimer levels in the presence of LAT.<h4>Methods</h4>We studied 244 AF patients with LAT (mean age: 59.9 years, SD:11.7; 53.3% female): of these, 103 (42.2%) had normal D-dimer, 25 (10.2%) had atrial thrombus exclusion score (ATE score) of 0 19 (16.7%) males had CHA<sub>2</sub>DS<sub>2</sub>-VASc score of 0, 21(16.2%) females had CHA<sub>2</sub>DS<sub>2</sub>-VASc score of 1 and 16 had overlapped ATE score of 0 and CHA<sub>2</sub>DS<sub>2</sub>-VASc score of 0 (N = 8 if male) or CHA<sub>2</sub>DS<sub>2</sub>-VASc score of 1(N = 8 if female). Using multivariate binary analysis, larger left atrial diameter (LAD; adjusted OR: 1.06, 1.03-1.10, p = 0.001) were associated with increased D-dimer. Patients with high body mass index (BMI), hypertension history and previous anticoagulation were more likely to show normal range D-dimer levels in the presence of LAT.<h4>Conclusions</h4>A high prevalence (42.2%) of 'normal range' D-dimer levels was found in AF patients with LAT, especially in those with hypertension, high BMI and prior anticoagulation. D-dimer levels of those patients with larger LAD were more likely to be increased.

Item Type:	Article
Uncontrolled Keywords:	atrial fibrillation, left atrial thrombus, d-dimer, left atrial diameter
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	28 Sep 2023 09:30
Last Modified:	28 Sep 2023 09:30
DOI:	10.1177/10760296221133380
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3173146