Chang, Pengxiang, Yang, Jiayun, Karunarathna, Thusitha K, Qureshi, Mehnaz, Sadeyen, Jean-Remy and Iqbal, Munir
(2023)
Characterization of the haemagglutinin properties of the H5N1 avian influenza virus that caused human infections in Cambodia.
EMERGING MICROBES & INFECTIONS, 12 (2).
2244091-.
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Characterization of the haemagglutinin properties of the H5N1 avian influenza virus that caused human infections in Cambodia.pdf - Open Access published version Download (801kB) | Preview |
Abstract
High pathogenicity avian influenza (HPAI) H5N1 is a subtype of the influenza A virus primarily found in birds. The subtype emerged in China in 1996 and has spread globally, causing significant morbidity and mortality in birds and humans. In Cambodia, a lethal case was reported in February 2023 involving an 11-year-old girl, marking the first human HPAI H5N1 infection in the country since 2014. This research examined the zoonotic potential of the human H5N1 isolate, A/Cambodia/NPH230032/2023 (KHM/23), by assessing its receptor binding, fusion pH, HA thermal stability, and antigenicity. Results showed that KHM/23 exhibits similar receptor binding and antigenicity as the early clade 2.3.2.1c HPAI H5N1 strain, and it does not bind to human-like receptors. Despite showing limited zoonotic risk, the increased thermal stability and reduced pH of fusion in KHM/23 indicate a potential threat to poultry, emphasizing the need for vigilant monitoring.
| Item Type: | Article |
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| Uncontrolled Keywords: | antigenicity, Cambodia, fusion pH, haemagglutinin thermal stability, poultry, receptor binding, zoonotic fatal Infections |
| Divisions: | Faculty of Health and Life Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 29 Sep 2023 09:48 |
| Last Modified: | 29 Sep 2023 09:48 |
| DOI: | 10.1080/22221751.2023.2244091 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173212 |
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