Kanji, Rahim, Gue, Ying X 
ORCID: 0000-0001-9994-8915, Farag, Mohamed F, Spencer, Neil H, Mutch, Nicola J and Gorog, Diana A
(2022)
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction.
JACC-BASIC TO TRANSLATIONAL SCIENCE, 7 (11).
pp. 1069-1082.
|
PDF
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction.pdf - Open Access published version Download (1MB) | Preview |
Abstract
Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: |  , fibrinolysis, myocardial infarction, platelet function, thrombosis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 29 Sep 2023 10:44 |
| Last Modified: | 29 Sep 2023 10:44 |
| DOI: | 10.1016/j.jacbts.2022.05.007 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173217 |
Dimensions
Dimensions
