Beier, Lea 
ORCID: 0000-0003-1861-0635, Lu, Shihai, França, Lionel Riou, Marler, Sabrina, Lip, Gregory YH ORCID: 0000-0002-7566-1626, Huisman, Menno V, Teutsch, Christine, Halperin, Jonathan L, Zint, Kristina, Diener, Hans-Christoph et al (show 8 more authors)
(2022)
Evolution of antithrombotic therapy for patients with atrial fibrillation: The prospective global GLORIA-AF registry program.
PloS one, 17 (10).
e0274237-.
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Evolution of antithrombotic therapy for patients with atrial fibrillation The prospective global GLORIA-AF registry program.pdf - Open Access published version Download (1MB) | Preview |
Abstract
<h4>Objective</h4>To assess baseline characteristics and antithrombotic treatment (ATT) prescription patterns in patients enrolled in the third phase of the GLORIA-AF Registry Program, evaluate predictors of treatment prescription, and compare results with phase II.<h4>Methods</h4>GLORIA-AF is a large, global, prospective registry program, enrolling patients with newly diagnosed nonvalvular atrial fibrillation (AF) at risk of stroke. Patients receiving dabigatran were followed for two years in phase II, and all patients were followed for 3 years in phase III. Phase II started when dabigatran became available; phase III started when the characteristics of patients receiving dabigatran became roughly comparable with those receiving vitamin K antagonists (VKAs).<h4>Results</h4>Between 2014 and 2016, 21,241 patients were enrolled in phase III. In total, 82% of patients were prescribed oral anticoagulation ([OAC]; 59.5% novel/nonvitamin K oral anticoagulants [NOACs], 22.7% VKAs). A further 11% of patients were prescribed antiplatelets without OAC and 7% were prescribed no ATT. A high stroke risk was the main driver of OAC prescription. Factors associated with prescription of VKA over NOAC included type of site, region, physician specialty, and impaired kidney function.<h4>Conclusion</h4>Over the past few years, data from phase III of GLORIA-AF show that OACs have become the standard treatment option, with most newly diagnosed AF patients prescribed a NOAC. However, in some regions a remarkable proportion of patients remain undertreated. In comparison with phase II, more patients received NOACs in phase III while the prescription of VKA decreased. VKAs were preferred over NOACs in patients with impaired kidney function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Atrial Fibrillation, Vitamin K, Fibrinolytic Agents, Anticoagulants, Administration, Oral, Registries, Stroke, Dabigatran |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 02 Oct 2023 14:08 |
| Last Modified: | 02 Oct 2023 14:09 |
| DOI: | 10.1371/journal.pone.0274237 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173303 |
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