Budnik, Monika, Gawałko, Monika 
ORCID: 0000-0003-4619-9062, Lodziński, Piotr, Tymińska, Agata, Ozierański, Krzysztof ORCID: 0000-0002-3848-0922, Grabowski, Marcin, Peller, Michał, Wancerz, Anna, Kiliszek, Marek, Opolski, Grzegorz ORCID: 0000-0003-4744-2554 et al (show 4 more authors)
(2023)
Heart failure in patients with atrial fibrillation: Insights from Polish part of the EORP-AF general long-term registry.
ESC heart failure, 10 (1).
pp. 637-649.
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Abstract
<h4>Aims</h4>This study aimed to determine the impact of heart failure (HF) on clinical outcomes in patients with atrial fibrillation (AF).<h4>Methods and results</h4>We analysed data from Polish participants of the EURObservational Research Programme-AF General Long-Term Registry. The primary endpoint was all-cause death, and the secondary endpoints included hospital readmissions, cardiovascular (CV) interventions, thromboembolic and haemorrhagic events, rhythm control interventions, and other CV or non-CV diseases development during one-year follow up. Overall, 688 patients with available data on HF were included into analysis; 51% (n = 351) had HF; of these 48% (n = 168) had reduced ejection fraction (HFrEF), 22% (n = 77) mid-range EF (HFmrEF), and 30% (n = 106) preserved EF (HFpEF). Compared with patients without HF, those with HF had higher mortality rate (aHR 5.61; 95% CI 1.94-16.22, P < 0.01). Patients with HF (vs. without HF) had more often CV interventions (10% vs. 5.4%, P = 0.046) and events (14% vs. 7.1%, P = 0.02), and had less often atrial arrhythmia-related hospital admissions (6.8% vs. 15%, P < 0.01). Over follow-up, patients with HFmrEF and HFpEF had similar mortality rate versus HFrEF (aHR 0.45, 95% CI 0.13-1.57, P = 0.45 for HFmrEF and aHR 0.54, 95% CI 0.20-1.48, P = 0.54 for HFpEF). Mortality rate was similar among rhythm versus rate control group (aHR 0.34; 95% CI 0.10-1.16; P = 0.34).<h4>Conclusions</h4>AF patients with HF have greater mortality rate and more CV interventions/events. No statistically significant difference in long-term outcomes between patients with HFrEF, HFmrEF, and HFpEF highlights the need to develop therapeutic strategies targeting functional status and survival for patients with HF and AF.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Atrial Fibrillation, Stroke Volume, Prognosis, Registries, Poland, Heart Failure |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 05 Oct 2023 10:17 |
| Last Modified: | 05 Oct 2023 11:44 |
| DOI: | 10.1002/ehf2.14130 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173447 |
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