Ferrara, Mariantonia, Gatti, Francesca, Lockington, David, Iaria, Antonio, Kaye, Stephen 
ORCID: 0000-0003-0390-0592, Virgili, Gianni, Aragona, Pasquale, Semeraro, Francesco and Romano, Vito ORCID: 0000-0002-5148-7643
(2023)
Antimicrobials and antiseptics: Lowering effect on ocular surface bacterial flora - A systematic review.
ACTA OPHTHALMOLOGICA, 102 (3).
e215-e228.
Abstract
Topical antimicrobials and antiseptics are used perioperatively to reduce the ocular surface bacteria flora (OSBF) that are involved in the development of post-operative infectious complications. However, their effectiveness is still a controversial topic. This systematic review, performed according to the PRISMA guidelines and registered in PROSPERO, aims to provide an overview of the efficacy of the agents currently used in peri-cataract surgery and -intravitreal injections (IVI) in lowering the OSBF. Although effective in lowering OSBF, perioperative topical antimicrobials are associated with the risk of resistance development, with no obvious additional benefit compared with topical antisepsis. Conversely, the effectiveness of topical antiseptics before cataract surgery and IVI is strongly supported. Based on the available evidence, perioperative antimicrobials are not recommended, whereas the perioperative use of antiseptics is strongly recommended as prophylactic treatment for lowering the infection due to OSBF. Post-operative antimicrobials may be considered in eyes at higher risk for infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cataract surgery, intravitreal injections, ocular surface bacterial flora, topical antimicrobials, topical antiseptics |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 05 Oct 2023 12:50 |
| Last Modified: | 12 Apr 2024 12:48 |
| DOI: | 10.1111/aos.15732 |
| Open Access URL: | https://doi.org/10.1111/aos.15732 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173451 |
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