Borgia, Alfredo, Pagano, Luca, Shah, Haider, Gadhvi, Kunal, Ahmad, Mohammad, Menassa, Nardine, Coco, Giulia, Kaye, Stephen 
ORCID: 0000-0003-0390-0592 and Romano, Vito ORCID: 0000-0002-5148-7643
(2023)
OP-2 Assessment of corneal angiography filling patterns in corneal neovascularization.
BMJ open ophthalmology, 8 (Suppl ).
A1-.
Abstract
*Correspondence, Alfredo Borgia: alfr.borgia@gmail.com PURPOSE: To describe vascular filling patterns in corneal neovascularization (CoNV) and evaluate the effect of corneal lesion location, CoNV surface area and multi-quadrant CoNV involvement on the filling pattern.<h4>Methods</h4>Retrospective study of patients who had been investigated for CoNV using fluorescein angiography (FA) or indocyanine green angiography (ICGA) between January 2010 and July 2020. Angiography images were graded and analysed multiple independent corneal specialists. Corneal surface was divided into 4 quadrants and patient information was obtained through electronic records.<h4>Results</h4>133 eyes were analysed. Corneal lesions were located on the peripheral (72%) or central (28%) cornea. Central lesions were associated with multi-quadrant CoNV more frequently than peripheral lesions (p=0.15). CoNV located within the same quadrant of the corneal lesion was often first to fill (88.4%). In multi-quadrant CoNV, the physiological inferior-superior-nasal-temporal order of filling was usually respected (61.7%). Central lesions resulted in larger CoNV surface area than to peripheral lesions (p=0.09). In multi-quadrant CoNV, the largest area of neovascularization was also the first to fill in (peripheral lesion 74%, central lesion 65%).<h4>Conclusion</h4>Fillings patterns in healthy corneas have previously been reported. Despite CoNV development, these patterns are usually respected. Several factors that may influence filling patterns have been identified, including corneal lesion location, CoNV surface area and aetiology of CoNV. Understanding filling patterns of neovascularization allows identification of areas at higher risk of developing CoNV, aiding in earlier detection and intervention of CoNV.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cornea, Humans, Corneal Neovascularization, Indocyanine Green, Fluorescein Angiography, Retrospective Studies, Coloring Agents |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 05 Oct 2023 13:18 |
| Last Modified: | 05 Oct 2023 13:19 |
| DOI: | 10.1136/bmjophth-2023-bcm.2 |
| Open Access URL: | http://dx.doi.org/10.1136/bmjophth-2023-BCM.2 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173460 |
Dimensions
Dimensions
