Hammarsten, Ola, Warner, Janet V, Lam, Leo, Kavsak, Peter, Lindahl, Bertil, Aakre, Kristin M, Collinson, Paul 
ORCID: 0000-0002-7000-5996, Jaffe, Allan S, Saenger, Amy K, Body, Richard et al (show 4 more authors)
(2023)
Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 61 (8).
pp. 1411-1419.
Abstract
The International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB) provides educational documents to facilitate the interpretation and use of cardiac biomarkers in clinical laboratories and practice. Our aim is to improve the understanding of certain key analytical and clinical aspects of cardiac biomarkers and how these may interplay. Measurements of cardiac troponin (cTn) have a prominent place in the clinical work-up of patients with suspected acute coronary syndrome. It is therefore important that clinical laboratories know how to recognize and assess analytical issues. Two emerging analytical issues resulting in falsely high cTn concentrations, often several fold higher than the upper reference limit (URL), are antibody-mediated assay interference due to long-lived cTn-antibody complexes, called macrotroponin, and crosslinking antibodies that are frequently referred to as heterophilic antibodies. We provide an overview of antibody-mediated cTn assay interference and provide recommendations on how to confirm the interference and interpret the results.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | assay interference, cardiac troponin, heterophile antibodies, immune complexes, macrotroponin, myocardial infarction |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Oct 2023 13:46 |
| Last Modified: | 06 Oct 2023 13:47 |
| DOI: | 10.1515/cclm-2023-0028 |
| Open Access URL: | https://doi.org/10.1515/cclm-2023-0028 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173502 |
Dimensions
Dimensions
