Lampignano, Luisa, Niro, Alfredo, Castellana, Fabio, Bortone, Ilaria, Zupo, Roberta, Tirelli, Sarah, Tatoli, Rossella, Griseta, Chiara, De Nucci, Sara, Sila, Annamaria et al (show 7 more authors)
(2022)
Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study.
FRONTIERS IN NEUROSCIENCE, 16.
1048375-.
Abstract
<h4>Background</h4>Age is a leading contributor to the liver fibrosis rate and a gradual deterioration of optical function, but this association in older populations is still under-explored. The present study aimed to explore the link between vascular and neural retinal characteristics and the risk of liver fibrosis in 731 older adults from the population-based Salus in Apulia study.<h4>Methods</h4>Retinal features were obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A). Liver fibrosis risk was taken as the fibrosis-4 (FIB-4) score. Generalized linear models (logistic regression) were used to estimate the association effect between each unit increase of OCT and OCT-A parameters as independent variables and a FIB-4 ≥ 2.67 score as an outcome. Generalized additive models were used to assess the non-linear association between OCT-A features and the linear FIB-4 score.<h4>Results</h4>Increased gangliar cell complex (GCC) thickness was inversely associated with a FIB-4 score above the cut-off in both the raw model (OR: 0.98; 95% CI: 0.96-0.99; SE: 0.01) and after adjustment for age, sex, education, hypertension, diabetes, total cholesterol, and triglycerides (OR: 0.98; 95% CI: 0.97-0.99; SE: 0.01).<h4>Conclusion</h4>Our findings add to the growing volume of scientific literature demonstrating that liver fibrosis is associated with retinal neurodegeneration. This study raises a number of new questions, including whether OCT-A may be used to track the progression of metabolic abnormalities and define exact thresholds for predicting and classifying liver disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | liver, fibrosis, retina, older population, aging |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Oct 2023 15:10 |
| Last Modified: | 06 Oct 2023 15:11 |
| DOI: | 10.3389/fnins.2022.1048375 |
| Open Access URL: | https://doi.org/10.3389/fnins.2022.1048375 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173507 |
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