Stefani, Chiara, Sangalli, Antonella, Locatelli, Elena, Federico, Tania, Malerba, Giovanni, Romanelli, Maria Grazia, Argañaraz, Gustavo Adolfo, Da Silva, Bosco Christiano Maciel, Da Silva, Alberto Jose Duarte, Casseb, Jorge et al (show 3 more authors)
(2022)
Increased Prevalence of Unstable HLA-C Variants in HIV-1 Rapid-Progressor Patients.
International journal of molecular sciences, 23 (23).
p. 14852.
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Abstract
HIV-1 infection in the absence of treatment results in progression toward AIDS. Host genetic factors play a role in HIV-1 pathogenesis, but complete knowledge is not yet available. Since less-expressed HLA-C variants are associated with poor HIV-1 control and unstable HLA-C variants are associated with higher HIV-1 infectivity, we investigated whether there was a correlation between the different stages of HIV-1 progression and the presence of specific HLA-C allotypes. HLA-C genotyping was performed using allele-specific PCR by analyzing a treatment-naïve cohort of 96 HIV-1-infected patients from multicentric cohorts in the USA, Canada, and Brazil. HIV-1-positive subjects were classified according to their different disease progression status as progressors (Ps, <i>n</i> = 48), long-term non-progressors (LTNPs, <i>n</i> = 37), and elite controllers (ECs, <i>n</i> = 11). HLA-C variants were classified as stable or unstable according to their binding stability to β2-microglobulin/peptide complex. Our results showed a significant correlation between rapid progression to AIDS and the presence of two or one unstable HLA-C variants (<i>p</i>-value: 0.0078, <i>p</i>-value: 0.0143, respectively). These findings strongly suggest a link between unstable HLA-C variants both at genotype and at allele levels and rapid progression to AIDS. This work provides further insights into the impact of host genetic factors on AIDS progression.
| Item Type: | Article |
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| Uncontrolled Keywords: | Humans, HIV-1, HIV Infections, Acquired Immunodeficiency Syndrome, Disease Progression, HLA-C Antigens |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Oct 2023 09:59 |
| Last Modified: | 30 Oct 2023 03:06 |
| DOI: | 10.3390/ijms232314852 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173521 |
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