Consiglio, Camila Rosat, Cotugno, Nicola, Sardh, Fabian, Pou, Christian, Amodio, Donato, Rodriguez, Lucie, Tan, Ziyang, Zicari, Sonia, Ruggiero, Alessandra 
ORCID: 0000-0001-6436-8814, Pascucci, Giuseppe Rubens et al (show 13 more authors)
(2020)
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.
CELL, 183 (4).
968-+.
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The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.pdf - Open Access published version Download (3MB) | Preview |
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. A complication is the rare multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, presenting 4-6 weeks after infection as high fever, organ dysfunction, and strongly elevated markers of inflammation. The pathogenesis is unclear but has overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology. We apply systems-level analyses of blood immune cells, cytokines, and autoantibodies in healthy children, children with Kawasaki disease enrolled prior to COVID-19, children infected with SARS-CoV-2, and children presenting with MIS-C. We find that the inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage. Finally, autoantibody profiling suggests multiple autoantibodies that could be involved in the pathogenesis of MIS-C.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CACTUS Study Team, T-Lymphocyte Subsets, Humans, Pneumonia, Viral, Coronavirus Infections, Mucocutaneous Lymph Node Syndrome, Proteome, Autoantibodies, Cytokines, Severity of Illness Index, Principal Component Analysis, Child, Child, Preschool, Infant, Female, Male, Systemic Inflammatory Response Syndrome, Immunity, Humoral, Pandemics, Betacoronavirus, COVID-19, SARS-CoV-2 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Oct 2023 09:39 |
| Last Modified: | 30 Oct 2023 03:08 |
| DOI: | 10.1016/j.cell.2020.09.016 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173538 |
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