Cotugno, Nicola, Ruggiero, Alessandra 
ORCID: 0000-0001-6436-8814, Bonfante, Francesco, Petrara, Maria Raffaella, Zicari, Sonia, Pascucci, Giuseppe Rubens, Zangari, Paola, De Ioris, Maria Antonietta, Santilli, Veronica, Manno, EC et al (show 12 more authors)
(2021)
Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies.
CELL REPORTS, 34 (11).
108852-.
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Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies.pdf - Open Access published version Download (3MB) | Preview |
Abstract
As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity to SARS-CoV-2 in children to define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) in 66 COVID-19-infected children at 7 (±2) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance and lower viral load associated with a reduced in vitro infectivity. We demonstrated that the frequencies of SARS-CoV-2-specific CD4<sup>+</sup>CD40L<sup>+</sup> T cells and Spike-specific B cells were associated with the anti-SARS-CoV-2 antibodies and the magnitude of neutralizing activity. The plasma proteome confirmed the association between cellular and humoral SARS-CoV-2 immunity, and PRNT<sup>+</sup> patients show higher viral signal transduction molecules (SLAMF1, CD244, CLEC4G). This work sheds lights on cellular and humoral anti-SARS-CoV-2 responses in children, which may drive future vaccination trial endpoints and quarantine measures policies.
| Item Type: | Article |
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| Uncontrolled Keywords: | CACTUS Study Team, B-Lymphocytes, CD4-Positive T-Lymphocytes, Humans, Proteome, Antibodies, Viral, Viral Load, Signal Transduction, Child, Adaptive Immunity, Immunity, Humoral, Antibodies, Neutralizing, COVID-19, SARS-CoV-2 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Oct 2023 09:33 |
| Last Modified: | 14 Mar 2024 17:54 |
| DOI: | 10.1016/j.celrep.2021.108852 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173539 |
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