Khimani, Faria, Wolf, Adam J, Yoon, Braian, Blancke, Amy, Gerhart, Coltin, Endsley, Dakota, Dougherty, Alleyna, Ray, Anish K, Yango, Angelito F, Flynn, Stuart D et al (show 3 more authors)
(2023)
Therapeutic considerations for prevention and treatment of thrombotic events in COVID-19.
Thrombosis Update, 10.
p. 100126.
Abstract
Thrombosis is a known complication of SARS-CoV-2 infection, particularly within a severely symptomatic subset of patients with COVID-19 disease, in whom an aggressive host immune response leads to cytokine storm syndrome (CSS). The incidence of thrombotic events coinciding with CSS may contribute to the severe morbidity and mortality observed in association with COVID-19. This review provides an overview of pharmacologic approaches based upon an emerging understanding of the mechanisms responsible for thrombosis across a spectrum of COVID-19 disease involving an interplay between immunologic and pro-thrombotic events, including endothelial injury, platelet activation, altered coagulation pathways, and impaired fibrinolysis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Rare Diseases, Prevention, Hematology, Clinical Research, 2.1 Biological and endogenous factors, 2 Aetiology, Blood, Cardiovascular, 3 Good Health and Well Being |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Oct 2023 13:42 |
| Last Modified: | 17 Mar 2024 16:04 |
| DOI: | 10.1016/j.tru.2022.100126 |
| Open Access URL: | https://doi.org/10.1016/j.tru.2022.100126 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173555 |
Dimensions
Dimensions
