Three-year outcomes of patients with non-valvular atrial fibrillation: the COOL-AF registry.

Krittayaphong, Rungroj, Pumprueg, Satchana, Kaewkumdee, Pontawee, Yindeengam, Ahthit and Lip, Gregory Yh ORCID: 0000-0002-7566-1626 (2023) Three-year outcomes of patients with non-valvular atrial fibrillation: the COOL-AF registry. Journal of geriatric cardiology : JGC, 20 (3). pp. 163-173.

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Official URL: http://dx.doi.org/10.26599/1671-5411.2023.03.008

Abstract

<h4>Background</h4>Clinical outcomes of patients with non-valvular atrial fibrillation (AF) in Asian populations may be different from non-Asians. In this study, we aimed to determine the incidence of ischemic stroke/systemic embolism (SSE), major bleeding, and death, and the predictors for clinical outcomes in a contemporary Asian cohort of newly diagnosed AF patients.<h4>Methods</h4>This is a prospective multicenter nationwide registry of patients with AF from 27 hospitals in Thailand. Baseline data and follow-up data were collected every 6 months until 3 years. Data collections included demographic, medical history, laboratory, and medication details. Clinical outcomes were SSE, major bleeding, and all-cause mortality. Incidence rates for each clinical outcome were calculated and presented as rate per 100 person-years. Univariate and multivariate analysis was performed to determine the independent predictors for clinical outcomes.<h4>Results</h4>There was a total of 3405 patients: mean age was 67.8 ± 11.3 years, 1981 (58.2%) were male. During 30.8 ± 9.7 months follow-up, there was a total of 132 SSE (3.9%), 191 major bleeding (5.6%), and 357 all-cause deaths (10.5%). The incidence rates of SSE, major bleeding, and death were 1.56 (1.30-1.84), 2.26 (1.96-2.61), and 4.17 (3.33-4.25), per 100 person-years respectively. Independent predictors for clinical outcomes were age, type of AF, and the presence of comorbid conditions.<h4>Conclusion</h4>The incidence rate of SSE, major bleeding, and death remains high reflecting the unmet needs in AF management.

Item Type:	Article
Uncontrolled Keywords:	Heart Disease, Cardiovascular, Clinical Research, Cardiovascular, 3 Good Health and Well Being
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	09 Oct 2023 13:43
Last Modified:	17 Mar 2024 16:29
DOI:	10.26599/1671-5411.2023.03.008
Open Access URL:	https://doi.org/10.26599/1671-5411.2023.03.008
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3173556