Byrne, Christina, Pareek, Manan, Krogager, Maria Lukacs, Ringgren, Kristian B, Wissenberg, Mads, Folke, Fredrik, Lippert, Freddy, Gislason, Gunnar, Kober, Lars, Sogaard, Peter et al (show 3 more authors)
(2021)
Increased 5-year risk of stroke, atrial fibrillation, acute coronary syndrome, and heart failure in out- of-hospital cardiac arrest survivors compared with population controls: A nationwide registry-based study.
RESUSCITATION, 169.
pp. 53-59.
Abstract
<h4>Aim</h4>Long-term risks of stroke, atrial fibrillation, or flutter (AF), acute coronary syndrome (ACS), and heart failure (HF) among survivors of out-of-hospital cardiac arrest (OHCA) are unknown. We aimed to examine 5-year risks of these outcomes among 30-day survivors of OHCA.<h4>Methods</h4>Thirty-day survivors of OHCA without a prior (or within 30 days after cardiac arrest) history of stroke, AF, ACS, or HF and population controls without a prior history of these conditions were identified using Danish nationwide registries. Five-year risks of stroke, AF, ACS, and HF standardized to the distributions of age, sex, and comorbidities among OHCA survivors and controls were obtained using multivariable regression.<h4>Results</h4>Of 4,362 30-day OHCA-survivors, 1,051 were stroke-, AF-, ACS-, and HF-naïve and matched with controls using age, sex, and time of OHCA event. Absolute five-year risks for OHCA survivors vs. controls were for stroke: 6.3% [95% confidence interval (CI) 4.1-8.5] vs. 2.0% [1.6-2.5], AF: 7.9% [5.7-10.2] vs. 2.6% [2.1-3.1], ACS: 5.0% [3.2-6.8] vs. 1.5% [1.1-1.9], and HF: 12.7% [10.1-15.4] vs. 1.2% [0.9-1.6], respectively. Corresponding relative risks were 3.18 [95% CI 1.76-4.61] for stroke, 3.03 [1.93-4.14] for AF, 3.23 [1.69-4.77] for ACS, and 10.40 [6.57-14.13] for HF.<h4>Conclusion</h4>When compared with population controls, OHCA survivors had significantly increased five-year risks of incident stroke, AF, ACS, and HF.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Out-of-hospital cardiac arrest survivors, Long-term risk, Stroke, Atrial fibrillation and atrial flutter, Acute coronary syndrome, Heart failure |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 12 Oct 2023 13:45 |
| Last Modified: | 12 Oct 2023 13:45 |
| DOI: | 10.1016/j.resuscitation.2021.10.024 |
| Open Access URL: | https://doi.org/10.1016/j.resuscitation.2021.10.02... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173624 |
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