Challen, Robert 
ORCID: 0000-0002-5504-7768, Dyson, Louise ORCID: 0000-0001-9788-4858, Overton, Christopher ORCID: 0000-0002-8433-4010, Guzman-Rincon, Laura ORCID: 0000-0003-4592-2896, Hill, Edward ORCID: 0000-0002-2992-2004, Stage, Helena, Brooks-Pollock, Ellen, Pellis, Lorenzo, Scarabel, Francesca, Pascall, David ORCID: 0000-0002-7543-0860 et al (show 12 more authors)
(2021)
Early epidemiological signatures of novel SARS-CoV-2 variants: establishment of B.1.617.2 in England.
[Preprint]
Abstract
The rapid emergence of SARS-CoV-2 mutants with new phenotypic properties is a critical challenge to the control of the ongoing pandemic. B.1.1.7 was monitored in the UK through routine testing and S-gene target failures (SGTF), comprising over 90% of cases by March 2021. Now, the reverse is occurring: SGTF cases are being replaced by an S-gene positive variant, which we associate with B.1.617.2. Evidence from the characteristics of S-gene positive cases demonstrates that, following importation, B.1.617.2 is transmitted locally, growing at a rate higher than B.1.1.7 and a doubling time between 5-14 days. S-gene positive cases should be prioritised for sequencing and aggressive control in any countries in which this variant is newly detected. <h4>One-Sentence Summary</h4> The B.1.617.2 variant of SARS-CoV-2 is replacing B.1.1.7 and emerging as the dominant variant in England, evidenced by sustained local transmission.
| Item Type: | Preprint |
|---|---|
| Uncontrolled Keywords: | Juniper |
| Divisions: | Faculty of Science and Engineering > School of Physical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 16 Oct 2023 08:15 |
| Last Modified: | 30 Oct 2023 02:52 |
| DOI: | 10.1101/2021.06.05.21258365 |
| Open Access URL: | https://doi.org/10.1101/2021.06.05.21258365 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173732 |
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