Muangnoicharoen, Sant
(2008)
The clinical pharmacology of artemisinin based drug combinations.
PhD thesis, University of Liverpool.
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Abstract
This thesis focuses on the clinical efficacy, pharmacokinetics and pharmacodynamics of artemisinin based drugs and their combinations for their treatment of P. falciparu11l malaria. The aims of the thesis are to get a better understanding of the basic pharmacology of artemisinin type drugs and their combinations. Chapter I is introduction and general knowledge about malaria disease, antimalarial drugs, treatment and drugs resistance. Chapter 2 determines parasite drug susceptibility and drug interaction of dihydroartemisinin and the quinoline type drug, piperaquine, used together as a fixed dose drug combination against P. falciparu11l in vitro. The results show that P. falciparu11l is highly susceptible to these two drugs even though when used in combination they show slight antagonism. Using a set of genetically manipulated parasites the data also showed a clear role for mutations in pferl to confer cross resistance to piperaquine and chloroquine. Chapter 3 focuses on the development of methods to accurately measure artesunate and dihydroartemisinin levels in human plasma. The method was highly sensitivity, robust and importantly reproducible. This method was subsequently used for th.e measurement of artemisinin type drug concentrations throughout my research.
| Item Type: | Thesis (PhD) |
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| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Oct 2023 09:24 |
| Last Modified: | 20 Oct 2023 09:46 |
| DOI: | 10.17638/03174394 |
| Copyright Statement: | Copyright © and Moral Rights for this thesis and any accompanying data (where applicable) are retained by the author and/or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3174394 |
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