Cronin Allen, John
(2008)
Neutrophil signalling via Fcγ receptors.
PhD thesis, University of Liverpool.
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Abstract
It has previously been shown that removal or blocking of the neutrophil receptor, FcyRIIIb (CD16b) completely prevented the ability of neutrophils to secrete reactive oxidants and granule enzymes in response to soluble immune complexes (SIC), but had no effect on the phagocytosis and killing of serum-opsonised Staphylococcus aureus. As soluble immune complexes are the major neutrophil activating factors in the synovial fluids of patients with rheumatoid arthritis, the aim of this work is to determine the intracellular signalling pathways regulated by FcYRIIIb to understand, in more detail, neutrophil function in disease.
| Item Type: | Thesis (PhD) |
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| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Oct 2023 09:24 |
| Last Modified: | 20 Oct 2023 09:44 |
| DOI: | 10.17638/03174420 |
| Copyright Statement: | Copyright © and Moral Rights for this thesis and any accompanying data (where applicable) are retained by the author and/or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3174420 |
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