Taccola, Giuliano, Kissane, Roger 
ORCID: 0000-0001-9385-2584, Culaclii, Stanislav, Apicella, Rosamaria, Liu, Wentai, Gad, Parag, Ichiyama, Ronaldo M, Chakrabarty, Samit and Edgerton, V Reggie
(2024)
Dynamic electrical stimulation enhances the recruitment of spinal interneurons by corticospinal input.
Experimental neurology, 371.
114589-.
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Abstract
Highly varying patterns of electrostimulation (Dynamic Stimulation, DS) delivered to the dorsal cord through an epidural array with 18 independent electrodes transiently facilitate corticospinal motor responses, even after spinal injury. To partly unravel how corticospinal input are affected by DS, we introduced a corticospinal platform that allows selective cortical stimulation during the multisite acquisition of cord dorsum potentials (CDPs) and the simultaneous supply of DS. Firstly, the epidural interface was validated by the acquisition of the classical multisite distribution of CDPs and their input-output profile elicited by pulses delivered to peripheral nerves. Apart from increased EMGs, DS selectively increased excitability of the spinal interneurons that first process corticospinal input, without changing the magnitude of commands descending from the motor cortex, suggesting a novel correlation between muscle recruitment and components of cortically-evoked CDPs. Finally, DS increases excitability of post-synaptic spinal interneurons at the stimulation site and their responsiveness to any residual supraspinal control, thus supporting the use of electrical neuromodulation whenever the motor output is jeopardized by a weak volitional input, due to a partial disconnection from supraspinal structures and/or neuronal brain dysfunctions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Spinal Cord, Pyramidal Tracts, Interneurons, Humans, Spinal Cord Injuries, Electric Stimulation, Evoked Potentials, Motor, Spinal Cord Stimulation |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 03 Nov 2023 11:32 |
| Last Modified: | 03 Feb 2024 08:44 |
| DOI: | 10.1016/j.expneurol.2023.114589 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3176503 |
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