DEPRESCRIBING LONG ACTING BETA2 AGONISTS INCHILDREN AND ADOLESCENTS WITH STABLE ASTHMA:A SYSTEMATIC REVIEW

Drozdz, Wiktoria, Sinha, Ian and Hawcutt, Daniel ORCID: 0000-0002-8120-6507 (2023) DEPRESCRIBING LONG ACTING BETA2 AGONISTS INCHILDREN AND ADOLESCENTS WITH STABLE ASTHMA:A SYSTEMATIC REVIEW. .

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Abstract

<jats:sec><jats:title>Introduction</jats:title><jats:p>We sought to detect a relationship between midazolam concentration and development of new delirium in critically ill children who were on continuous midazolam administration.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Delirium was detected using the Sophia Observation withdrawal Symptoms - Paediatric Delirium (SOS-PD) score and 104 left-over samples were available to measure midazolam concentrations.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Twenty-five percent of the included patients developed new delirium. Median cumulative midazolam dose was higher in patients who developed delirium compared to those without delirium but lower compared with the day preceding delirium detection, indicative of a rapid decline. Similar findings were made when active metabolites 1-hydroxymidazolam and 1-hydroxymidazolam glucuronide were considered.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>A sudden and significant reduction in midazolam concentration may contribute to the development of a delirium in critically ill children. </jats:p></jats:sec>

Item Type:	Conference or Workshop Item (Unspecified)
Uncontrolled Keywords:	Brain Disorders, Acquired Cognitive Impairment
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	06 Nov 2023 16:58
Last Modified:	02 Apr 2024 09:25
DOI:	10.1136/archdischild-2023-ESDPPP.32
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3176611