Transsphenoidal hypophysectomy for the treatment of hypersomatotropism secondary to a pituitary somatotroph adenoma in a dog

Steele, Matthew ME, Lawson, Jack S, Scudder, Christopher, Watson, Alice H, Ho, Nicola TZ, Yaffy, Dylan, Batchelor, Daniel ORCID: 0000-0003-0141-9711 and Fenn, Joe (2023) Transsphenoidal hypophysectomy for the treatment of hypersomatotropism secondary to a pituitary somatotroph adenoma in a dog. Journal of Veterinary Internal Medicine, 38 (1). pp. 351-357.

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Official URL: http://dx.doi.org/10.1111/jvim.16929

Abstract

<jats:title>Abstract</jats:title><jats:p>Pituitary‐dependent hypersomatotropism is rarely diagnosed in dogs and surgical treatment is not reported. A 6‐year‐10‐month male neutered Patterdale Terrier presented with polyuria, polydipsia, progressive pharyngeal stertor, excessive hair growth and widened facial features and paws. Serum insulin‐like growth factor‐1 concentration via radioimmunoassay was consistent with hypersomatotropism (1783 ng/mL). A pituitary mass was identified on magnetic resonance and computed tomography imaging. Six weeks later, glucosuria, starved hyperglycemia and serum fructosamine above the reference range (467.6 μmol/L, RI 177‐314) were documented, consistent with diabetes mellitus. Transsphenoidal hypophysectomy was performed under general anesthesia without complications. Pituitary histopathology identified an acidophil neoplasm, with positive immunostaining for growth hormone. Postoperatively, there was rapid resolution of clinical, biochemical and morphologic changes of hypersomatotropism with persistence of diabetes mellitus. This case demonstrates successful resolution of hypersomatotropism with ongoing diabetes mellitus in a dog after surgical treatment by transsphenoidal hypophysectomy.</jats:p>

Item Type:	Article
Uncontrolled Keywords:	Animals, Dogs, Adenoma, Pituitary Neoplasms, Acromegaly, Diabetes Mellitus, Dog Diseases, Hypophysectomy, Male, Growth Hormone-Secreting Pituitary Adenoma
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	13 Nov 2023 10:15
Last Modified:	10 Feb 2024 01:51
DOI:	10.1111/jvim.16929
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3176765