Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies.

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Wan, Wenxin ORCID: 0000-0002-1957-4034, Peters, Susan ORCID: 0000-0001-5662-1971, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas et al (show 30 more authors) , Kendzia, Benjamin ORCID: 0000-0002-8662-795X, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K ORCID: 0000-0003-3951-6365, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans and Vermeulen, Roel ORCID: 0000-0003-4082-8163 (2024) Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies. American journal of respiratory and critical care medicine, 209 (2). pp. 185-196.

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Abstract

<b>Rationale:</b> Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. <b>Objectives:</b> We aimed to examine the relationship between occupational benzene exposure and lung cancer. <b>Methods:</b> Subjects from 14 case-control studies across Europe and Canada were pooled. We used a quantitative job-exposure matrix to estimate benzene exposure. Logistic regression models assessed lung cancer risk across different exposure indices. We adjusted for smoking and five main occupational lung carcinogens and stratified analyses by smoking status and lung cancer subtypes. <b>Measurements and Main Results:</b> Analyses included 28,048 subjects (12,329 cases, 15,719 control subjects). Lung cancer odds ratios ranged from 1.12 (95% confidence interval, 1.03-1.22) to 1.32 (95% confidence interval, 1.18-1.48) (<i>P</i>_trend = 0.002) for groups with the lowest and highest cumulative occupational exposures, respectively, compared with unexposed subjects. We observed an increasing trend of lung cancer with longer duration of exposure (<i>P</i>_trend < 0.001) and a decreasing trend with longer time since last exposure (<i>P</i>_trend = 0.02). These effects were seen for all lung cancer subtypes, regardless of smoking status, and were not influenced by specific occupational groups, exposures, or studies. <b>Conclusions:</b> We found consistent and robust associations between different dimensions of occupational benzene exposure and lung cancer after adjusting for smoking and main occupational lung carcinogens. These associations were observed across different subgroups, including nonsmokers. Our findings support the hypothesis that occupational benzene exposure increases the risk of developing lung cancer. Consequently, there is a need to revisit published epidemiological and molecular data on the pulmonary carcinogenicity of benzene.

Item Type:	Article
Uncontrolled Keywords:	Lung, Humans, Lung Neoplasms, Occupational Diseases, Benzene, Carcinogens, Case-Control Studies, Occupational Exposure
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	14 Nov 2023 13:56
Last Modified:	20 Jan 2024 01:16
DOI:	10.1164/rccm.202306-0942oc
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3176797